Cross-reactive idiotypes and common antigen binding specificities expressed by a series of murine B-cell lymphomas: etiological implications.
Cross-reactive idiotypes and common antigen binding specificities expressed by a series of murine B-cell lymphomas: etiological implications.
复制标题
一系列鼠 B 细胞淋巴瘤表达的交叉反应独特型和常见抗原结合特异性：病因学意义。
DOI：
10.1073/pnas.82.11.3799
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发表时间：
1985
影响因子：
11.1
通讯作者：
Haughton,G
中科院分区：
文献类型：
--
作者：
Pennell,CA;Arnold,LW;Lutz,PM;LoCascio,NJ;Willoughby,PB;Haughton,G
在B10.H-2aH-4 b p/Wts小鼠中通过绵羊红细胞强过继免疫诱导的一系列27例B细胞淋巴瘤（命名为CH系列）被发现代表了总B细胞库的一个子集。该亚组的特征为表达有限数量的IG重链可变区，这可通过存在交叉反应性独特型和共同抗原结合特异性来证明。研究的27个CH淋巴瘤中有21个被分为5组，由特定的交叉反应独特型定义;其中4组在一个网络中相连。通过吸收分析确定的16个独特型中的7个存在于具有κ或λ轻链的淋巴瘤上，因此定位于重链可变区。发现14 CH淋巴瘤表面的IG对某些红细胞（菠萝蛋白酶处理的自体红细胞、绵羊和鸡红细胞）或E.杆菌我们认为CH淋巴瘤代表B10. H-2aH-4 B p/Wts小鼠中一组独特相关的正常B细胞的恶性对应物。这种独特型网络的干扰，通过使用某些成员特异性的抗原（绵羊红细胞）进行超免疫，增加了肿瘤形成的风险。对此可能的机制进行了讨论。
A series of 27 B-cell lymphomas (designated the CH series), induced in B10.H-2aH-4b p/Wts mice by intense adoptive immunization with sheep erythrocytes, was found to represent a subset of the total B-cell repertoire. This subset was characterized by expression of a limited number of Ig heavy chain variable regions, as evidenced by the presence of cross-reactive idiotypes and common antigen binding specificities. Twenty-one of the 27 CH lymphomas studied were classified into five groups, defined by a particular cross-reactive idiotype; four of these groups were linked in a single network. Seven of 16 idiotypes defined by absorption analysis were present on lymphomas bearing either kappa or lambda light chains and so were localized to the heavy chain variable region. The surface Ig on 14 CH lymphomas was found to be specific for epitopes on certain erythrocytes (bromelain-treated autologous erythrocytes, sheep, and chicken erythrocytes) or E. coli. We propose that the CH lymphomas represent the malignant counterparts of a subset of idiotypically related, normal B cells in B10.H-2aH-4b p/Wts mice. Perturbation of this idiotype network, by hyperimmunization with an antigen for which some of the members are specific (sheep erythrocytes), increases the risk for neoplasia. Possible mechanisms for this are discussed.