The familiality of pelvic organ prolapse in the Utah Population Database.
The familiality of pelvic organ prolapse in the Utah Population Database.
复制标题
犹他州人口数据库中盆腔器官脱垂的家族性。
DOI：
10.1007/s00192-012-1866-0
复制
发表时间：
2013
影响因子：
1.8
通讯作者：
Cannon-Albright,LisaA
中科院分区：
文献类型：
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作者：
Norton,PeggyA;Allen-Brady,Kristina;Cannon-Albright,LisaA
前言和假设女性盆腔器官脱垂(POP)是一种常见的疾病，其病因尚不清楚。越来越多的证据表明，流行音乐是可遗传的。我们研究的目的是定义和评估POP的家族聚集性。方法使用基于人群的犹他州家系，结合十多年的医院数据，我们使用年龄和出生年份特定的POP发生率来计算POP女性亲属中POP的相对危险度(RR)。我们使用遗传距离来比较所有POP病例与人群的平均成对关联度。结果我们确定了1,292名具有POP诊断和程序代码的女性。一级和三级女性亲属POP的RR显著升高(RR4.15，p<； 0.001；RR1.24，p= 0.05)。所有POP患者的平均配对关联度显著高于预期(P<； 0.001)。结论这些结果有力地支持了POP的显著遗传贡献。
Introduction and hypothesisPelvic organ prolapse (POP) in women is a common condition whose etiology is poorly understood. There is increasing evidence that POP is heritable. The aim of our study was to define and evaluate familial clustering of POP.MethodsUsing a population-based Utah genealogy linked to more than a decade of hospital data, we calculated relative risks (RR) of POP in female relatives of women with POP using age- and birth year-specific rates of POP. We compared the average pairwise relatedness of all POP cases to the population using a measure of genetic distance.ResultsWe identified 1,292 women with diagnostic and procedure codes for POP. The RR of POP was significantly elevated in first- and third-degree female relatives (RR 4.15,p< 0.001; RR 1.24,p= 0.05). The average pairwise relatedness for all individuals with POP was significantly higher than expected (p< 0.001).ConclusionsThese results strongly support a significant heritable contribution to POP.