Relationships between serum unsaturated fatty acids and coronary risk factors - Negative relations between nervonic acid and obesity-related risk factors
Relationships between serum unsaturated fatty acids and coronary risk factors - Negative relations between nervonic acid and obesity-related risk factors
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DOI：
10.1536/ihj.46.975
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发表时间：
2005-11-01
影响因子：
1.5
通讯作者：
Watanabe, K
中科院分区：
文献类型：
--
作者：
Oda, E;Hatada, K;Watanabe, K
饮食中不饱和脂肪酸（USFA）的相对增加被认为对冠状动脉危险因素（CRF）有有益的影响。然而，关于血清USFA与CRF之间关系的详细分析很少，神经酸（NA）与CRR之间的关系尚未见报道。本研究旨在分析血清USFA与CRF之间的关系。测定了31例男性（41 ~ 78岁）和11例女性（54 ~ 77岁）的身高、体重、血压、空腹血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDLc）、空腹血糖（FBS）、总脂肪酸组成、瘦素和高敏c反应蛋白（CRP）。采用多元回归分析血清USFA与体重指数（BMI）、瘦素、收缩压（SBP）、舒张压（DBP）、TC、TG、HDLc、FBS、CRP的关系。最终结果用冠状动脉危险因素评分（CRFS）进行总结，以评估USFA与CRF之间的相关性。油酸（OA）、亚油酸（LA）和二十碳五烯酸（EPA）与冠状动脉危险因素呈正相关（总CRFS = 2,3和4）。神经酸（NA）对这些危险因素均有负作用（总CRFS = -6）。结论NA对肥胖相关代谢紊乱具有预防作用。
Relative increases in unsaturated fatty acids (USFA) in the diet are considered to exert beneficial effects on coronary risk factors (CRF). However, detailed analysis of the relationships between serum USFA and CRF are scanty and there is no report of the relationship between nervonic acid (NA) and CRR The objective of the present Study was to analyze the relationships between serum USFA and CRF.Body height and weight, blood pressure, fasting serum total cholesterol (TC), triacylglycerol (TG), HDL cholesterol (HDLc), fasting blood Sugar (FBS), total fatty acid composition, leptin, and high-sensitivity C-reactive protein (CRP) were measured in 3 1 men (age, 41-78 years) and 11 women (age, 54-77 years). The relationships between serum USFA, and body mass index (BMI), leptin, systolic blood pressure (SBP), diastolic blood pressure (DBP), TC, TG, HDLc, FBS, and CRP were analyzed using multiple regression analysis. The final results were summarized using coronary risk factor scores (CRFS) in order to assess the correlations between USFA with CRF.Oleic acid (OA), linoleic acid (LA), and eicosapentaenoic acid (EPA) were positively related to coronary risk factors (total CRFS = 2, 3, and 4. respectively), while nervonic acid (NA) exerted negative effects on these risk factors (total CRFS = -6). It is concluded NA may have preventive effects on obesity-related metabolic disorders.