Imaging and Therapy of Pancreatic Cancer with Phosphatidylserine-Targeted Nanovesicles.
Imaging and Therapy of Pancreatic Cancer with Phosphatidylserine-Targeted Nanovesicles.
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DOI：
10.1016/j.tranon.2015.03.011
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发表时间：
2015-06
影响因子：
5
通讯作者：
Qi, Xiaoyang
中科院分区：
文献类型：
--
作者：
Blanco, Victor M.;Latif, Tahir;Chu, Zhengtao;Qi, Xiaoyang
胰腺癌仍然是最难治性的癌症之一，其预后很差，5年生存率约为6%。由于早期疾病症状不明确，缺乏特异性生物标志物，大约80%的患者出现晚期，无法手术的肿瘤，这是一个艰巨的挑战。尽管进行了许多临床试验，但没有一种化疗药物与客观缓解率超过10%或中位生存期超过5至7个月可靠相关。虽然近年来联合化疗方案提供了一些改善，但总生存期（8-11个月）仍然很差。因此，迫切需要能够改善胰腺癌患者预后的新疗法。在这里，我们总结了目前用于晚期胰腺癌管理的治疗方法，并回顾了针对肿瘤生物标志物的新治疗策略。我们还描述了我们最近使用磷脂酰丝氨酸靶向皂素c偶联二酰基磷脂酰丝氨酸纳米囊泡用于胰腺癌成像和治疗的研究。
Pancreatic cancer remains one of the most intractable cancers, with a dismal prognosis reflected by a 5-year survival of ~ 6%. Since early disease symptoms are undefined and specific biomarkers are lacking, about 80% of patients present with advanced, inoperable tumors that represent a daunting challenge. Despite many clinical trials, no single chemotherapy agent has been reliably associated with objective response rates above 10% or median survival longer than 5 to 7 months. Although combination chemotherapy regimens have in recent years provided some improvement, overall survival (8-11 months) remains very poor. There is therefore a critical need for novel therapies that can improve outcomes for pancreatic cancer patients. Here, we present a summary of the current therapies used in the management of advanced pancreatic cancer and review novel therapeutic strategies that target tumor biomarkers. We also describe our recent research using phosphatidylserine-targeted saposin C–coupled dioleoylphosphatidylserine nanovesicles for imaging and therapy of pancreatic cancer.
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影响因子：
28.2
作者：
Collisson EA;Trejo CL;Silva JM;Gu S;Korkola JE;Heiser LM;Charles RP;Rabinovich BA;Hann B;Dankort D;Spellman PT;Phillips WA;Gray JW;McMahon M
通讯作者：
McMahon M
影响因子：
6.2
作者：
Colucci, G;Giuliani, F;Lopez, M
通讯作者：
Lopez, M
影响因子：
3.7
作者：
Chu, Zhengtao;Abu-Baker, Shadi;Qi, Xiaoyang
通讯作者：
Qi, Xiaoyang
影响因子：
29.4
作者：
Cappello, Paola;Rolla, Simona;Novelli, Francesco
通讯作者：
Novelli, Francesco
影响因子：
11.2
作者：
Blackford A;Parmigiani G;Kensler TW;Wolfgang C;Jones S;Zhang X;Parsons DW;Lin JC;Leary RJ;Eshleman JR;Goggins M;Jaffee EM;Iacobuzio-Donahue CA;Maitra A;Klein A;Cameron JL;Olino K;Schulick R;Winter J;Vogelstein B;Velculescu VE;Kinzler KW;Hruban RH
通讯作者：
Hruban RH