Hippo signaling: A hub of growth control, tumor suppression and pluripotency maintenance
Hippo signaling: A hub of growth control, tumor suppression and pluripotency maintenance
复制标题
Hippo 信号传导：生长控制、肿瘤抑制和多能性维持的枢纽
DOI：
10.1016/j.jgg.2011.09.009
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发表时间：
2011-10-01
影响因子：
5.9
通讯作者：
Zhang, Lei
中科院分区：
文献类型：
--
作者：
Yin, Mengxin;Zhang, Lei
器官大小调控的分子机制仍然是发育生物学中尚未解开的主要谜团之一。大约十年前，在果蝇身上发现了河马信号通路，为这个令人困惑的问题提供了一些线索。河马信号通路在无脊椎动物和脊椎动物中都高度保守，在动物发育中起着关键作用。它通过抑制细胞增殖和促进细胞凋亡来控制器官的大小和生长。河马信号通路的故障会导致癌症的发展和肿瘤的发生。虽然信号通路的核心已经被很好地理解了，但上游的输入和下游的转录调控对我们来说仍然是未知的。本文综述了目前对河马信号通路的机制和功能的认识，并比较了其在果蝇和哺乳动物中的差异。我们强调了河马信号通路与其他信号通路之间的串扰，以及河马信号通路在干细胞增殖和自我更新中的可能作用。
The molecular mechanisms of organ size control and regulation remain one of the major unsolved mysteries of development biology. Almost a decade ago, the discovery of the Hippo signaling pathway in Drosophila shed some light on this puzzling issue. The Hippo signaling pathway is highly conserved in both invertebrates and vertebrates, and plays critical roles in animal development. It controls organ size and growth by inhibiting cell proliferation and by promoting apoptosis. Malfunction of the Hippo signaling pathway leads to cancer development and tumorigenesis. Although the core of the signaling pathway is well understood, the upstream inputs and downstream transcriptional regulation are still obscure to us. In this review, we summarize the current understanding of the mechanism and the function of the Hippo signaling pathway and compare its differences between flies and mammals. We underline the crosstalk between the Hippo signaling pathway and other signaling pathways, and the possible roles of the Hippo pathway in stem cell proliferation and self-renewal.