A prospective study of dietary fat consumption and endometriosis risk
A prospective study of dietary fat consumption and endometriosis risk
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DOI：
10.1093/humrep/deq044
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发表时间：
2010-06-01
影响因子：
6.1
通讯作者：
Hankinson, Susan E.
中科院分区：
文献类型：
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作者：
Missmer, Stacey A.;Chavarro, Jorge E.;Hankinson, Susan E.
背景：子宫内膜异位症是一种普遍但神秘的妇科疾病，几乎没有可改变的危险因素被确定。在女性原发性痛经的研究中，食用鱼油与改善症状有关，在自体移植动物实验中，食用鱼油与降低子宫内膜异位症的风险有关。方法：为了研究膳食脂肪摄入与子宫内膜异位症风险的关系，我们分析了始于1989年的护士健康研究II中12年的前瞻性数据。1991年、1995年和1999年通过食物频率问卷对膳食脂肪进行了评估。我们使用COX比例风险模型校正了18岁时的总能量摄入量、产次、种族和体重指数，并评估了三个饮食问卷的累积平均脂肪摄入量。结果：在586,153人年的随访中，报告了1199例经腹腔镜确诊的子宫内膜异位症患者。尽管总脂肪摄入量与子宫内膜异位症的风险无关，但长链omega-3脂肪酸摄入量最高的五分之一的女性与摄入量最低的五分之一的女性相比，诊断为子宫内膜异位症的可能性低22%[95%可信区间(CI)=0.62-0.99；P值，线性趋势检验(PT)=0.03]。此外，反式不饱和脂肪摄入量最高的五分之一的人患子宫内膜异位症的几率高48%(95%CI=17-1.88；PT=0.001)。结论：这些数据表明，特定类型的饮食脂肪与腹腔镜确诊的子宫内膜异位症的发病率有关，这些关系可能表明这些关系可能是可改变的风险。这一证据还提供了另一种疾病关联，支持从食品供应中去除氢化油中的反式脂肪的努力。
Background: Endometriosis is a prevalent but enigmatic gynecologic disorder for which few modifiable risk factors have been identified. Fish oil consumption has been associated with symptom improvement in studies of women with primary dysmenorrhea and with decreased endometriosis risk in autotransplantation animal studies.Methods: To investigate the relation between dietary fat intake and the risk of endometriosis, we analyzed 12 years of prospective data from the Nurses' Health Study II that began in 1989. Dietary fat was assessed via food frequency questionnaire in 1991, 1995 and 1999. We used Cox proportional hazards models adjusted for total energy intake, parity, race and body mass index at age 18, and assessed cumulatively averaged fat intake across the three diet questionnaires.Results: During the 586 153 person-years of follow-up, 1199 cases of laparoscopically confirmed endometriosis were reported. Although total fat consumption was not associated with endometriosis risk, those women in the highest fifth of long-chain omega-3 fatty acid consumption were 22% less likely to be diagnosed with endometriosis compared with those with the lowest fifth of intake [95% confidence interval (CI) = 0.62-0.99; P-value, test for linear trend (Pt) = 0.03]. In addition, those in the highest quintile of trans-unsaturated fat intake were 48% more likely to be diagnosed with endometriosis (95% CI = 17-1.88; Pt = 0.001).Conclusion: These data suggest that specific types of dietary fat are associated with the incidence of laparoscopically confirmed endometriosis, and that these relations may indicate modifiable risk. This evidence additionally provides another disease association that supports efforts to remove trans fat from hydrogenated oils from the food supply.