Ramelteon modulates gamma oscillations in the rat primary motor cortex during non-REM sleep
Ramelteon modulates gamma oscillations in the rat primary motor cortex during non-REM sleep
复制标题
Ramelteon 在非快速眼动睡眠期间调节大鼠初级运动皮层的伽马振荡
DOI：
10.1016/j.jphs.2020.11.006
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发表时间：
2021
影响因子：
3.5
通讯作者：
Nobuyoshi Matsumoto
中科院分区：
文献类型：
--
作者：
Airi Yoshimoto;Kotaro Yamashiro;Takeshi Suzuki;Yuji Ikegaya;Nobuyoshi Matsumoto
睡眠障碍对日常活动产生不利影响，并导致生理和精神问题。苯二氮卓类催眠药的缺点导致了褪黑素MT 1和MT 2激动剂雷美替酮的开发。尽管雷美替翁的促睡眠作用已有文献记载，但很少有研究精确地研究睡眠结构和神经振荡活动。在这项研究中，我们记录了在初级运动皮层，初级躯体感觉皮层和嗅球，以及肌电图与雷美替酮或车辆处理的无约束大鼠的皮层电图。使用基于神经振荡的算法将大鼠的行为分为三种警惕状态（例如，清醒、快速眼动（REM）睡眠和非REM（NREM）睡眠）。此外，我们调查的区域，频率和状态的特定调制的细胞外振荡的雷美替恩治疗的大鼠。我们证明，与苯二氮卓类药物治疗相反，雷美替酮治疗促进了NREM睡眠，并增强了NREM睡眠期间初级运动皮层中的快γ功率，而REM睡眠不受影响。伽马振荡局部协调神经元放电，因此，ramelteon以独特的方式调节睡眠状态下的神经振荡，并可能有助于睡眠期间的离线信息处理。
Sleep disorders adversely affect daily activities and cause physiological and psychiatric problems. The shortcomings of benzodiazepine hypnotics have led to the development of ramelteon, a melatonin MT1and MT2agonist. Although the sleep-promoting effects of ramelteon have been documented, few studies have precisely investigated the structure of sleep and neural oscillatory activities. In this study, we recorded electrocorticograms in the primary motor cortex, the primary somatosensory cortex and the olfactory bulb as well as electromyograms in unrestrained rats treated with either ramelteon or vehicle. A neural-oscillation-based algorithm was used to classify the behavior of the rats into three vigilance states (e.g., awake, rapid eye movement (REM) sleep, and non-REM (NREM) sleep). Moreover, we investigated the region-, frequency- and state-specific modulation of extracellular oscillations in the ramelteon-treated rats. We demonstrated that in contrast to benzodiazepine treatment, ramelteon treatment promoted NREM sleep and enhanced fast gamma power in the primary motor cortex during NREM sleep, while REM sleep was unaffected. Gamma oscillations locally coordinate neuronal firing, and thus, ramelteon modulates neural oscillations in sleep states in a unique manner and may contribute to off-line information processing during sleep.