Parietal dysfunction during number processing in children with fetal alcohol spectrum disorders.
Parietal dysfunction during number processing in children with fetal alcohol spectrum disorders.
复制标题
患有胎儿酒精谱系障碍的儿童在数字处理过程中的顶叶功能障碍。
DOI：
10.1016/j.nicl.2015.03.023
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Jacobson,JL
中科院分区：
文献类型：
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作者：
Woods,KJ;Meintjes,EM;Molteno,CD;Jacobson,SW;Jacobson,JL
数字处理缺陷经常见于产前接触酒精的儿童。虽然顶叶，这是已知的调解数处理的几个关键方面，已被证明是在胎儿酒精谱系障碍（FASD）的结构受损，在这个地区的功能活动的影响，在数字处理以前没有被调查。这项对49名儿童进行的功能磁共振成像研究，使用简单加法和大小比较任务，检查了与产前酒精暴露相关的5个关键顶叶区域参与数字处理的激活差异。尽管一般相似的行为表现，在这两项任务中，更大的产前酒精暴露有关的右水平顶内沟的前部激活较少，已知介导的心理表征和操纵的数量。胎儿酒精综合征和部分胎儿酒精综合征的儿童似乎弥补了这一赤字增加激活的角回在幅度比较任务。
Number processing deficits are frequently seen in children prenatally exposed to alcohol. Although the parietal lobe, which is known to mediate several key aspects of number processing, has been shown to be structurally impaired in fetal alcohol spectrum disorders (FASD), effects on functional activity in this region during number processing have not previously been investigated. This fMRI study of 49 children examined differences in activation associated with prenatal alcohol exposure in five key parietal regions involved in number processing, using tasks involving simple addition and magnitude comparison. Despite generally similar behavioral performance, in both tasks greater prenatal alcohol exposure was related to less activation in an anterior section of the right horizontal intraparietal sulcus known to mediate mental representation and manipulation of quantity. Children with fetal alcohol syndrome and partial fetal alcohol syndrome appeared to compensate for this deficit by increased activation of the angular gyrus during the magnitude comparison task.