Proximal pulmonary artery blood flow characteristics in healthy subjects measured in an upright posture using MRI: The effects of exercise and age
Proximal pulmonary artery blood flow characteristics in healthy subjects measured in an upright posture using MRI: The effects of exercise and age
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DOI：
10.1002/jmri.20333
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发表时间：
2005-06-01
影响因子：
4.4
通讯作者：
Feinstein, JA
中科院分区：
文献类型：
--
作者：
Cheng, CP;Herfkens, RJ;Feinstein, JA
目的：利用MRI量化健康儿童和成人在休息和直立姿势运动时肺动脉近端血流状况。材料与方法：在配备直立式MRI兼容测功仪的开放式MRI磁体上，使用Cine相对比MRI计算健康儿童和成人主（MPA）、右（RPA）和左（LPA）肺动脉的平均流量和逆流指数（RFI）。结果：从休息到运动（150%静息心率），RPA (1.4 +/- 0.3 vs. 2.5 +/- 0.4, P < 0.001), LPA （1.1 +/- 0.3 vs. 2.2 +/- 0.6, P < 0.001）和MPA （2.7 +/- 0.5 vs. 4.9 +/- 0.5, P < 0.001）的血流量（升/分钟/m(2)）增加。RFI在LPA组（0.040 +/- 0.030 vs. 0.017 +/- 0.018, P < 0.02）和MPA组（0.025 +/- 0.024 vs. 0.008 +/- 0.007, P < 0.03）降低。成人MPA逆行血流大于儿童（0.042 +/- 0.029 vs. 0.014 +/- 0.012, P < 0.02）。结论：在休息和运动时，儿童和成人的RPA/LPA平均血流分布主要由远端血管阻力决定，而逆行血流受近端肺分叉几何形状的影响。
Purpose: To use MRI to quantify blood flow conditions in the proximal pulmonary arteries of healthy children and adults at rest and during exercise in an upright posture.Materials and Methods: Cine phase-contrast MRI was used to calculate mean flow and reverse flow index (RFI) in the main (MPA), right (RPA), and left (LPA) pulmonary arteries in healthy children and adults in an open-MRI magnet equipped with an upright MRI-compatible ergometer.Results: From rest to exercise (150% resting heart rate), blood flow (liters/minute/m(2)) increased in the RPA (1.4 +/- 0.3 vs. 2.5 +/- 0.4; P < 0.001), LPA (1.1 +/- 0.3 vs. 2.2 +/- 0.6; P < 0.001), and MPA (2.7 +/- 0.5 vs. 4.9 +/- 0.5: P < 0.001). RFI decreased in the LPA (0.040 +/- 0.030 vs. 0.017 +/- 0.018; P < 0.02) and MPA (0.025 +/- 0.024 vs. 0.008 +/- 0.007; P < 0.03). Adults experienced greater retrograde flow in the MPA than the children (0.042 +/- 0.029 vs. 0.014 +/- 0.012; P < 0.02).Conclusion: It appears that at both rest and during exercise, in children and adults alike, RPA/LPA mean blood flow distribution is predominantly determined by distal vascular resistance, while retrograde flow is affected by proximal pulmonary bifurcation geometry.