The three-panel runway maze adapted to Microcebus murinus reveals age-related differences in memory and perseverance performances.
The three-panel runway maze adapted to Microcebus murinus reveals age-related differences in memory and perseverance performances.
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适应鼠鼠的三板跑道迷宫揭示了记忆力和毅力表现与年龄相关的差异。
DOI：
10.1016/j.nlm.2010.04.006
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发表时间：
2010
影响因子：
2.7
通讯作者：
Mestre-Frances,Nadine
中科院分区：
文献类型：
--
作者：
Trouche,StephanieG;Maurice,Tangui;Rouland,Sylvie;Verdier,Jean-Michel;Mestre-Frances,Nadine
鼠狐猴（Microcebus murinus）是一种有价值的脑老化研究模型，也是阿尔茨海默病模型的重要动物，因为它们可以随着年龄的增长形成β-淀粉样蛋白斑块。虽然大脑老化的生物学和生物化学分析是有据可查的，但这种灵长类动物的认知能力还没有得到彻底的表征。在这项研究中，我们采用了啮齿动物的空间工作记忆程序，在三面板跑道的顺序选择任务，鼠狐猴。我们分析了年龄相关的差异，在程序性记忆任务中的视觉线索的存在或不存在。60%的年轻成年狐猴和48%的老年狐猴在程序开始时完成了探索，选择习惯和测试阶段。年轻的成年狐猴表现出较高水平的持续错误与老年动物相比，特别是在视觉刺激的存在下。在随机水平下，老年动物比年轻动物产生更多的参照错误，从而快速提高了它们的成绩。在年轻人和老年人中没有观察到显着改善。本研究表明，M. murinus评估的顺序选择任务中的三个面板的跑道显着不同，从以前报道的啮齿动物的能力。年轻成年狐猴的行为反应的影响新奇相关的焦虑，有助于他们的表现在持续性错误。相反，老年狐猴表现出较少的持续错误，快速适应三面板跑道迷宫，但更多的记忆错误。总的来说，这些发现表明了使用三面板跑道任务评估记忆性能的可行性，特别是在老年鼠狐猴中。
Microcebus murinus, a mouse lemur primate appears to be a valuable model for cerebral aging study and for Alzheimer’s disease model since they can develop β-amyloid plaques with age. Although the biological and biochemical analyses of cerebral aging are well documented, the cognitive abilities of this primate have not been thoroughly characterized. In this study, we adapted a spatial working memory procedure described in rodents, the sequential choice task in the three-panel runway, to mouse lemurs. We analyzed the age-related differences in a procedural memory task in the absence or presence of visual cues. Sixty percent of young adult and 48% of aged lemurs completed the exploratory, choice habituation and testing phases at the beginning of the procedure. Young adult lemurs showed a higher level of perseverative errors compared with aged animals, particularly in the presence of visual stimuli. Over trials, old animals made more reference errors compared to young ones that improved quickly their performances under random level. No significant improvement was observed in young adults and old ones over sessions. This study showed that behavioural performances of M. murinus assessed on the sequential choice task in the three-panel runway markedly differ from the previously reported abilities of rodents. The behavioural response of young adult lemurs was influenced by novelty-related anxiety that contributed to their performance in terms of perseverative errors. Conversely, aged lemurs showed less perseverative errors, a rapid habituation to the three-panel runway maze, but made more memory errors. Overall, these findings demonstrate the feasibility to use the three-panel runway task in assessing memory performance, particularly in aged mouse lemurs.