Effects of changes in intraocular pressure on human ocular haemodynamics
Effects of changes in intraocular pressure on human ocular haemodynamics
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DOI：
10.1076/ceyr.16.10.1024.9024
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发表时间：
1997-10-01
影响因子：
2
通讯作者：
Schmetterer, L
中科院分区：
文献类型：
--
作者：
Findl, O;Strenn, K;Schmetterer, L
目的.肌源性自身调节是血管床在灌注压变化的情况下维持血流的能力。眼灌注压定义为眼动脉压和眼静脉压之间的差值，后者取决于眼内压（IOP）。本研究的目的是研究眼压中度升高对眼血流动力学的影响。用负压吸引法使10名健康受试者眼压升高（+10 mmHg，+ 20 mmHg），激光干涉法测量黄斑和视盘的眼底搏动，多普勒超声测量视网膜中央动脉（CRA）和眼动脉（OA）的血流速度。眼压的变化引起眼底搏动的显著减少，这在黄斑部更为明显（+ 10 mmHg：-9 +/-2%，p < 0.01;+ 20 mmHg：-19 +/-3%，p < 0.001）（在+ 10 mmHg下：-5 +/-2%（ns）;在+ 20 mmHg下：-9 +/-3%，p < 0.01）。CRA中的平均流速在+ 10 mmHg（ns）下降低了-5 +/- 3%，在+ 20 mmHg下降低了-14 +/- 5%（p < 0.005），阻力指数在+ 10 mmHg下增加了+ 4 +/- 1%（p < 0.05），在+ 20 mmHg下增加了+ 6 +/- 2%（p < 0.01）。相反，IOP的升高并不影响OA的血流参数。我们的眼底搏动测量结果表明，脉络膜血流量减少时，眼压升高。CRA中的多普勒超声检查结果表明，在IOP升高期间，该动脉中的血流速度降低。
Purpose. Myogenic autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. Ocular perfusion pressure is defined as the difference between ocular arterial pressure and ocular venous pressure the latter dependent on intraocular pressure (IOP). The aim of the present study was to investigate the effect of moderate increases in IOP on ocular haemodynamics.Methods. Changes in IOP (+10 mmHg, + 20 mmHg) were induced by a suction cup in 10 healthy subjects, Ocular fundus pulsations in the macula and the optic disc were measured by laser interferometry; blood flow velocities in the central retinal artery (CRA) and in the ophthalmic artery (OA) were measured by Doppler sonography.Results. Changes in IOP caused a significant reduction in fundus pulsations, which was more pronounced in the macula (at + 10 mmHg: -9 +/- 2%, p < 0.01; at + 20 mmHg: -19 +/- 3%, p < 0.001) than in the optic disc (at + 10 mmHg: -5 +/- 2% (ns); at + 20 mmHg: -9 +/- 3%, p < 0.01). Mean flow velocity in the CRA was reduced by -5 +/- 3% at + 10 mmHg (ns) and by -14 +/- 5% at + 20 mmHg (p < 0.005), resistive index was increased by + 4 +/- 1% at + 10 mmHg (p < 0.05) and by + 6 +/- 2% at + 20 mmHg (p < 0.01). In contrast, a rise in IOP did not affect blood flow parameters in the OA.Conclusions. Our results from fundus pulsation measurements indicate that choroidal blood flow decreases when IOP is increased. The Doppler sonographic findings in the CRA indicate reduced blood how velocity in this artery during raised IOP.