Blood levels of cytokines in elderly patients with major depressive disorder
Blood levels of cytokines in elderly patients with major depressive disorder
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DOI：
10.1111/j.1600-0447.1998.tb10005.x
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发表时间：
1998-04-01
影响因子：
6.7
通讯作者：
Maggioni, M
中科院分区：
文献类型：
--
作者：
Brambilla, F;Maggioni, M
测定10例老年抑郁症患者和10例健康女性青年志愿者的血浆IL-1β、IL-6和肿瘤坏死因子-α(TNF-α)水平。用600 mg/d的磷脂酰丝氨酸(BC-PS)治疗30天前后检测MDD患者细胞因子水平。青年对照组、老年对照组和MDD患者的血浆IL-1β、IL-6和TNF-α浓度无显著差异。BC-PS治疗虽然显著改善了抑郁症状，但并没有改变细胞因子的浓度。
Plasma concentrations of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF alpha) were measured in 10 elderly women with major depressive disorder (MDD) and in two groups of controls, one consisting of 10 age-matched healthy female volunteers and one consisting of 10 young healthy female volunteers. The cytokine concentrations were measured in MDD patients before and after 30 days of treatment with phosphatidylserine (BC-PS), 600 mg daily p.o. The plasma IL-1 beta, IL-6 and TNF alpha concentrations did not differ significantly in young controls, elderly controls and MDD patients. BC-PS therapy, while significantly improving the depressive symptoms, did not alter the cytokine concentrations.