Mushroom body output differentiates memory processes and distinct memory-guided behaviors
Mushroom body output differentiates memory processes and distinct memory-guided behaviors
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DOI：
10.1016/j.cub.2020.12.032
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发表时间：
2021-03-22
期刊：
影响因子：
9.2
通讯作者：
Tanimoto, Hiromu
中科院分区：
文献类型：
--
作者：
Ichinose, Toshiharu;Kannot, Mai;Tanimoto, Hiromu
黑腹果蝇的蘑菇体（MB）在控制记忆和行为方面具有多种功能。(1-9)然而，产生这种功能多样性的电路机制在很大程度上还不清楚。在这里，我们系统地探讨了每种类型的MB输出神经元（MBON）的行为贡献，在收购，保留，或检索奖励或惩罚记忆的阻塞。我们评估的贡献，使用两个条件反射：记忆引导的气味选择和气味源的吸引力。定量分析表明，这些条件性气味反应是由不同的MBON控制的。我们发现，记忆的效价，而不是记忆步骤的过渡，对所需的MBON的模式有更大的影响。此外，我们发现，形成循环回路的杏仁核能MBON通常有助于食欲记忆的获得，这表明该回路基序在奖励加工中起着关键作用。我们的研究结果提供了MB输出电路如何处理不同效价的联想记忆和控制不同的记忆引导行为的原则。
The mushroom body (MB) of Drosophila melanogaster has multiple functions in controlling memory and behavior.(1-9) However, circuit mechanisms that generate this functional diversity are largely unclear. Here, we systematically probed the behavioral contribution of each type of MB output neuron (MBON) by blocking during acquisition, retention, or retrieval of reward or punishment memories. We evaluated the contribution using two conditioned responses: memory-guided odor choice and odor source attraction. Quantitative analysis revealed that these conditioned odor responses are controlled by different sets of MBONs. We found that the valence of memory, rather than the transition of memory steps, has a larger impact on the patterns of required MBONs. Moreover, we found that the glutamatergic MBONs forming recurrent circuits commonly contribute to appetitive memory acquisition, suggesting a pivotal role of this circuit motif for reward processing. Our results provide principles how the MB output circuit processes associative memories of different valence and controls distinct memory-guided behaviors.