Investigating hormone-induced changes in affective state using the affective bias test in male and female rats.
Investigating hormone-induced changes in affective state using the affective bias test in male and female rats.
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使用雄性和雌性大鼠的情感偏差测试来研究激素引起的情感状态变化。
DOI：
10.1016/j.psyneuen.2020.104647
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发表时间：
2020
影响因子：
3.7
通讯作者：
Hinchcliffe JK
中科院分区：
文献类型：
--
作者：
Hinchcliffe JK
最近的临床和临床前研究表明，情感偏见可能在情绪障碍的发展和延续中发挥重要作用。对动物的研究也表明，类似的神经心理过程可以在非人类物种中测量，使用旨在测量学习、记忆或决策偏差的行为分析。考虑到激素和情绪之间的联系，我们使用情感偏差测试来研究不同激素治疗对雄性和雌性大鼠的影响。动物在学习两种独立的底物-奖励关联之前，预先接受了急性剂量的激素或载体控制。在随后的选择测试中，动物对药物治疗过程中习得的底物的偏好分别为正偏或负偏。在两性中，雌二醇和雌激素样化合物双酚A诱导正向偏倚，而用福美斯坦阻断雌激素诱导负向偏倚。黄体酮在两性中引起负偏倚，但睾酮只在男性中引起负偏倚。氟他胺阻断睾酮在较高剂量（10 mg/kg）下诱导两性阳性偏倚。催产素的类似物卡比催产素在两性中都引起了积极的偏向，而抗利尿激素的类似物去氨加压素只在雄性大鼠中引起了积极的偏向。这些结果提供了使用外源性治疗调节激素水平可以诱导大鼠情感偏差的证据。他们还认为，激素引起的情感偏见会影响认知和情感行为，并可能对一些情绪障碍产生长期影响。
Recent clinical and pre-clinical research suggests that affective biases may play an important role in the development and perpetuation of mood disorders. Studies in animals have also revealed that similar neuropsychological processes can be measured in non-human species using behavioural assays designed to measure biases in learning and memory or decision-making. Given the proposed links between hormones and mood, we used the affective bias test to investigate the effects of different hormone treatments in both male and female rats. Animals were pre-treated with acute doses of hormone or vehicle control prior to learning each of two independent substrate-reward associations. During a subsequent choice test, positive or negative biases were observed by animal’s preference towards or away from the substrate learnt during drug treatment respectively. In both sexes, oestradiol and the oestrogen-like compound bisphenol A induced positive biases, whilst blockade of oestrogen hormones with formestane induced a negative bias. Progesterone induced a negative bias in both sexes, but testosterone only induced a negative bias in males. Blocking testosterone with flutamide induced a positive bias in both sexes at the higher dose (10 mg/kg). The oxytocin analogue, carbetocin induced positive biases in both sexes but the vasopressin analogue, desmopressin, induced a positive bias in male rats only. These results provide evidence that modulating levels of hormones using exogenous treatments can induce affective biases in rats. They also suggest that hormone-induced affective biases influence cognitive and emotional behaviour and could have longer-term effects in some mood disorders.