OLFACTORY DETECTION AND IDENTIFICATION PERFORMANCE ARE DISSOCIATED IN EARLY ALZHEIMERS-DISEASE
OLFACTORY DETECTION AND IDENTIFICATION PERFORMANCE ARE DISSOCIATED IN EARLY ALZHEIMERS-DISEASE
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DOI：
10.1212/wnl.38.8.1228
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发表时间：
1988-08-01
期刊：
影响因子：
9.9
通讯作者：
FRIEDLAND, RP
中科院分区：
文献类型：
--
作者：
KOSS, E;WEIFFENBACH, JM;FRIEDLAND, RP
对10名经过仔细筛选的阿尔茨海默病患者S病(AD)患者和10名年龄相仿的健康对照组进行了气味识别和味觉检测等多项化学感觉任务的比较。患者在气味识别和提供三叉神经刺激的空气中刺激的子集上的得分明显低于对照组。相比之下，患者的嗅觉和味觉检测阈值与对照组相比并未受到损害。患者的神经心理测试得分和18F-2脱氧-D-葡萄糖PET检查结果与任何化学感觉措施都没有相关性。孤立的气味识别缺陷表明，AD患者最初的化学感觉障碍是中枢的，而不是外周的。
Ten carefully screened men with very mild symptoms of Alzheimer''s disease (AD) and ten healthy controls of similar age were compared on multiple chemosensory tasks: odor detection and identification, and taste detection. The patients scored significantly worse than controls on identification of odors and of a subset of airborne stimuli providing trigeminal stimulation. In contrast, the patients'' olfactory detection thresholds as well as taste detection thresholds were not impaired relative to those of controls. The patients'' scores on neuropsychological tests and the results 18F-2 deoxy-D-glucose PET studies did not correlate with any of the chemosensory measures. The isolated odor identification deficit suggests that the initial chemosensory impairment in AD is central rather than peripheral.