Mixed Phenotype Acute Leukemia A Study of 61 Cases Using World Health Organization and European Group for the Immunological Classification of Leukaemias Criteria
Mixed Phenotype Acute Leukemia A Study of 61 Cases Using World Health Organization and European Group for the Immunological Classification of Leukaemias Criteria
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DOI：
10.1309/ajcppvupotuvoib5
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发表时间：
2014-12-01
影响因子：
3.5
通讯作者：
Arber, Daniel A.
中科院分区：
文献类型：
--
作者：
Weinberg, Olga K.;Seetharam, Mahesh;Arber, Daniel A.
目的：2008年世界卫生组织(WHO)分类系统将双系急性白血病和双表型急性白血病归为混合型急性白血病(MPAL)。诊断MPAL的谱系特异性标记标准也发生了变化。方法：采用欧洲白血病免疫分类组织(EGIL)标准和2008年WHO标准对61例MPAL患者进行研究。结果：16例(26%)急性双表型白血病患者不符合2008年WHO标准。有32例患者有细胞遗传学资料，最常见的异常是t(9；22)(5/32)。临床结果数据显示，较年轻的MPAL患者(
Objectives: The 2008 World Health Organization (WHO) classification system grouped bilineal and biphenotypic acute leukemias together under a new heading of mixed phenotype acute leukemia (MPAL). The lineage-specific marker criteria have also changed for a diagnosis of MPAL. The goal of this study was to characterize clinical significance of this new group.Methods: Sixty-one patients diagnosed with MPAL using either European Group for the Immunological Classification of Leukaemias (EGIL) criteria or 2008 WHO criteria were included in this study.Results: Sixteen patients (26%) diagnosed with acute biphenotypic leukemia using EGIL criteria did not fulfill 2008 WHO criteria for MPAL. Cytogenetic data were available for 32 patients, and the most common abnormality was t(9;22) (five of 32 cases). Clinical outcome data suggested that younger patients with MPAL (