Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research.
Establishing a framework to implement 4D XCAT phantom for 4D radiotherapy research.
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DOI：
10.4103/0973-1482.106539
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发表时间：
2012-10
影响因子：
1.3
通讯作者：
Cai J
中科院分区：
文献类型：
--
作者：
Panta RK;Segars P;Yin FF;Cai J
建立用于4D放射治疗（RT）研究的4D集成扩展心脏躯干（XCAT）数字体模的实现框架。开发了一个计算机程序，以促进4D XCAT体模的表征和实施。该程序可以（1）使用自定义参数文件生成4D XCAT图像;（2）查看4D XCAT图像;（3）从4D XCAT图像生成合成图像;（4）跟踪选定感兴趣区域（ROI）的运动;（5）将XCAT原始二进制图像转换为DICOM格式;（6）分析临床采集的4DCT图像和实时位置管理（RPM）呼吸信号。通过与手动方法的比较，验证了运动跟踪算法的有效性.研究了4D XCAT体模的主要特性。病变运动轨迹的运动跟踪和手动测量之间的比较显示两者之间存在微小差异（运动幅度的平均差异：1.2 mm）。最大病变运动几乎线性下降（R2 = 0.97），其距离隔膜（DD）的增加。在任何给定的DD，病变运动幅度增加几乎线性（R2范围：0.89至0.95）作为输入的隔膜运动增加。对于给定的横膈膜运动，病变运动与任何给定DD处的病变大小无关。4D XCAT体模可逼真再现不规则呼吸轮廓。端到端测试表明，可以基于4D XCAT图像成功生成临床可比的治疗计划。一个集成的计算机程序已经开发出来，以生成，审查，分析，处理和导出的4D XCAT图像。已经建立了一个框架，以实现4D RT研究的4D XCAT体模。
To establish a framework to implement the 4D integrated extended cardiac torso (XCAT) digital phantom for 4D radiotherapy (RT) research. A computer program was developed to facilitate the characterization and implementation of the 4D XCAT phantom. The program can (1) generate 4D XCAT images with customized parameter files; (2) review 4D XCAT images; (3) generate composite images from 4D XCAT images; (4) track motion of selected region-of-interested (ROI); (5) convert XCAT raw binary images into DICOM format; (6) analyse clinically acquired 4DCT images and real-time position management (RPM) respiratory signal. Motion tracking algorithm was validated by comparing with manual method. Major characteristics of the 4D XCAT phantom were studied. The comparison between motion tracking and manual measurements of lesion motion trajectory showed a small difference between them (mean difference in motion amplitude: 1.2 mm). The maximum lesion motion decreased nearly linearly (R2 = 0.97) as its distance to the diaphragm (DD) increased. At any given DD, lesion motion amplitude increased nearly linearly (R 2 range: 0.89 to 0.95) as the inputted diaphragm motion increased. For a given diaphragm motion, the lesion motion is independent of the lesion size at any given DD. The 4D XCAT phantom can closely reproduce irregular breathing profile. The end-to-end test showed that clinically comparable treatment plans can be generated successfully based on 4D XCAT images. An integrated computer program has been developed to generate, review, analyse, process, and export the 4D XCAT images. A framework has been established to implement the 4D XCAT phantom for 4D RT research.