Transplantation in mesangiocapillary glomerulonephritis with intramembranous dense "deposits": recurrence of disease.
Transplantation in mesangiocapillary glomerulonephritis with intramembranous dense "deposits": recurrence of disease.
复制标题
膜内致密“沉积物”的系膜毛细血管性肾小球肾炎的移植：疾病复发。
DOI：
10.1038/ki.1976.54
复制
发表时间：
1976
影响因子：
19.6
通讯作者：
Leibowitz
中科院分区：
文献类型：
--
作者：
D. Turner;J. Cameron;M. Bewick;P. Sharpstone;D. Melcher;C. Ogg;D. Evans;A. J. Trafford;Leibowitz
六名患有系膜毛细血管性肾小球肾炎和膜内致密“沉积物”的患者出现了终末期肾衰竭并进行了移植，其中三名来自活体供体，三名来自尸体供体。移植后 1 至 26 个月期间，从其中 5 个移植物中获取了 8 个肾活检标本。移植后七个月后采集的所有六个活检标本均显示肾小球基底膜以及鲍曼氏囊和管状基底膜中致密膜内“沉积物”的复发。 “沉积物”的复发与免疫荧光研究中除一份样本外的所有样本中的 C3 沉积有关；此外，在两个标本中发现了IgM，但不存在IgG和早期补体成分。然而，只有两名患者表现出与大量蛋白尿相关的肾小球增殖。在其他受试者中，“沉积物”的复发与临床发现无关。两名患者发生移植物损失，主要是由于排斥反应。
Six patients with mesangiocapillary glomerulonephritis and intramembranous dense "deposits" developed terminal renal failure and were transplanted, three from living and three from cadaver donors. Eight renal biopsy specimens were obtained from five of the grafts, from 1 to 26 months following transplantation. All six biopsy specimens taken later than seven months following the graft showed recurrence of dense intramembranous "deposits" in the basement membranes of glomeruli, and of Bowman's capsule and tubular basement in five. Recurrence of "deposits" was associated with deposition of C3 on immunofluorescent study in all but one specimen; in addition, IgM was found in two specimens, but IgG and early complement components were absent. Only two patients, however, showed glomerular proliferation associated with profuse proteinuria. In the other subjects the recurrence of the "deposit" was not associated with clinical findings. Graft loss, which occurred in two patients, was predominantly from rejection.