REQUIREMENT OF VASCULAR INTEGRIN ALPHA(V)BETA(3) FOR ANGIOGENESIS
REQUIREMENT OF VASCULAR INTEGRIN ALPHA(V)BETA(3) FOR ANGIOGENESIS
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DOI：
10.1126/science.7512751
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发表时间：
1994-04-22
期刊：
影响因子：
56.9
通讯作者：
CHERESH, DA
中科院分区：
文献类型：
--
作者：
BROOKS, PC;CLARK, RAF;CHERESH, DA
血管生成依赖于血管细胞的粘附相互作用。粘附受体整合素α（v）β（3）被鉴定为血管生成血管组织的标志物。整合素α（v）β（3）在人伤口肉芽组织的血管上表达，但在正常皮肤中不表达，并且在鸡绒毛尿囊膜上的血管生成过程中其表达增加了4倍。在后一项试验中，α（v）β（3）的单克隆抗体阻断了碱性成纤维细胞生长因子、肿瘤坏死因子-α和人黑色素瘤片段诱导的血管生成，但对先前存在的血管没有影响。这些发现表明，α（v）β（3）可能是一个有用的治疗靶点的疾病特点是新血管形成。
Angiogenesis depends on the adhesive interactions of vascular cells. The adhesion receptor integrin alpha(v) beta(3), was identified as a marker of angiogenic vascular tissue. Integrin alpha(v) beta(3), was expressed on blood vessels in human wound granulation tissue but not in normal skin, and it showed a fourfold increase in expression during angiogenesis on the chick chorioallantoic membrane. In the latter assay, a monoclonal antibody to alpha(v) beta(3), blocked angiogenesis induced by basic fibroblast growth factor, tumor necrosis factor-alpha, and human melanoma fragments but had no effect on preexisting vessels. These findings suggest that alpha(v) beta(3) may be a useful therapeutic target for diseases characterized by neovascularization.