Maxillary sinus grafting with Bio-Oss® or Straumann® Bone Ceramic:: histomorphometric results from a randomized controlled multicenter clinical trial
Maxillary sinus grafting with Bio-Oss® or Straumann® Bone Ceramic:: histomorphometric results from a randomized controlled multicenter clinical trial
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DOI：
10.1111/j.1600-0501.2008.01565.x
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发表时间：
2008-08-01
影响因子：
4.3
通讯作者：
Chiapasco, Matteo
中科院分区：
文献类型：
--
作者：
Cordaro, Luca;Bosshardt, Dieter D.;Chiapasco, Matteo
介绍：本研究旨在比较无机牛骨（ABB）和新型双相磷酸钙骨陶瓷（BCP）用于上颌窦底提升术的组织形态计量学结果。残留骨宽度>= 6 mm，高度>= 3 mm且< 8 mm。使用外侧窦提升，使用ABB（对照组; 23个窦）或BCP（试验组; 25个窦）进行移植;将部位随机分配到对照组或试验组。愈合180-240天后，创建植入部位，并进行组织学和组织形态学分析。评估的参数为（1）移植区域中新骨、软组织和移植替代材料的面积分数;（2）剩余牙槽嵴室中骨和软组织成分的面积分数;以及（3）移植替代材料和新骨之间的表面接触百分比。56%的试验部位和81.8%的对照部位可获得可测量的活检。组织学显示两组的新骨和移植物颗粒之间紧密接触，试验和对照部位的活检治疗室中矿化骨量无显著差异（BCP为21.6 +/- 10.0%，ABB为19.8 +/- 7.9%; P=0.53）。发现ABB的骨-移植物接触显著更大（48.2 +/- 12.9% vs. BCP的34.0 +/- 14.0%）。BCP组中移植物替代材料的剩余百分比显著更低（26.6 +/- 5.2% vs. ABB的37.7 +/- 8.5%; P=0.001），软组织成分更多（46.4 +/- 7.7% vs. ABB的40.4 +/- 7.3%; P=0.07）。然而，两组的软组织成分的量被发现是不大于在剩余的alveolar ridge.Discussion：ABB和BCP都产生了类似数量的新形成的骨，具有相似的组织学外观，这表明这两种材料都适合用于窦增强牙种植体的放置。更多软组织成分和BCP不同吸收特征的潜在临床相关性需要进一步研究。
Introduction: This investigation was designed to compare the histomorphometric results from sinus floor augmentation with anorganic bovine bone (ABB) and a new biphasic calcium phosphate, Straumann (R) Bone Ceramic (BCP).Materials and methods: Forty-eight maxillary sinuses were treated in 37 patients. Residual bone width was >= 6 mm and height was >= 3 mm and < 8 mm. Lateral sinus augmentation was used, with grafting using either ABB (control group; 23 sinuses) or BCP (test group; 25 sinuses); sites were randomly assigned to the control or test groups. After 180-240 days of healing, implant sites were created and biopsies taken for histological and histomorphometric analyses. The parameters assessed were (1) area fraction of new bone, soft tissue, and graft substitute material in the grafted region; (2) area fraction of bone and soft tissue components in the residual alveolar ridge compartment; and (3) the percentage of surface contact between the graft substitute material and new bone.Results: Measurable biopsies were available from 56% of the test and 81.8% of the control sites. Histology showed close contact between new bone and graft particles for both groups, with no significant differences in the amount of mineralized bone (21.6 +/- 10.0% for BCP vs. 19.8 +/- 7.9% for ABB; P=0.53) in the biopsy treatment compartment of test and control site. The bone-to-graft contact was found to be significantly greater for ABB (48.2 +/- 12.9% vs. 34.0 +/- 14.0% for BCP). Significantly less remaining percentage of graft substitute material was found in the BCP group (26.6 +/- 5.2% vs. 37.7 +/- 8.5% for ABB; P=0.001), with more soft tissue components (46.4 +/- 7.7% vs. 40.4 +/- 7.3% for ABB; P=0.07). However, the amount of soft tissue components for both groups was found not to be greater than in the residual alveolar ridge.Discussion: Both ABB and BCP produced similar amounts of newly formed bone, with similar histologic appearance, indicating that both materials are suitable for sinus augmentation for the placement of dental implants. The potential clinical relevance of more soft tissue components and different resorption characteristics of BCP requires further investigation.