Adult asthma associated with roadway density and housing in rural Appalachia: the Mountain Air Project (MAP).
Adult asthma associated with roadway density and housing in rural Appalachia: the Mountain Air Project (MAP).
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DOI：
10.1186/s12940-023-00984-x
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发表时间：
2023-03-27
影响因子：
6
通讯作者：
Browning, Steven R.
中科院分区：
文献类型：
--
作者：
Christian, W. Jay;Flunker, John;May, Beverly;Westneat, Susan;Sanderson, Wayne T.;Schoenberg, Nancy;Browning, Steven R.
阿巴拉契亚肯塔基州是一个农村地区，成人哮喘患病率很高。环境暴露在这些人群中成人哮喘病因中的相对贡献尚未得到充分研究。本手稿描述了山地空气项目 (MAP) 的目标、研究设计、方法和参与者的特征，并重点关注小区域环境暴露（包括道路和采矿作业）与成人终生和当前哮喘之间的关联。肯塔基州两个县的一群 21 岁及以上的居民参加了一项基于社区的横断面研究。分层整群抽样用于选择表示为 14 位 USGS 水文单位 (HUC) 的小地理区域。对选定的 HUC 内的家庭进行了统计。社区卫生工作者进行了面对面的访谈。所有 HUC 均描述了附近活跃和不活跃煤矿开采作业的邻近性、石油和天然气作业的密度以及道路的密度。泊松回归分析用于估计调整后的患病率。从1,459户符合条件的家庭中，招募了1,190人，完成了访谈972人。终生哮喘患病率为 22.8%；目前哮喘率为16.3%。调整协变量后，在第二个三分位数（aPR = 1.61；95% CI 1.04–2.48）和第三个三分位数（aPR = 2.00；95% CI 1.32–3.03）中，道路密度与当前哮喘呈正相关。与居住在单户住宅中相比，居住在公共多单元住房中当前哮喘风险增加（aPR = 2.01；95% CI 1.27–3.18）。靠近煤矿开采和石油和天然气作业与哮喘患病率之间没有显着关联。这项研究表明，在考虑其他已知的危险因素后，道路密度较高的农村地区的居民和居住在公共住房单元的居民当前患哮喘的风险可能会增加。本研究确认交通相关颗粒物在成年人哮喘高风险中的作用，有助于了解影响阿巴拉契亚地区呼吸健康的多种环境暴露。
Appalachian Kentucky is a rural area with a high prevalence of asthma among adults. The relative contribution of environmental exposures in the etiology of adult asthma in these populations has been understudied. This manuscript describes the aims, study design, methods, and characteristics of participants for the Mountain Air Project (MAP), and focuses on associations between small area environmental exposures, including roadways and mining operations, and lifetime and current asthma in adults. A cohort of residents, aged 21 and older, in two Kentucky counties, was enrolled in a community-based, cross-sectional study. Stratified cluster sampling was used to select small geographic areas denoted as 14-digit USGS hydrologic units (HUCs). Households were enumerated within selected HUCs. Community health workers collected in-person interviews. The proximity of nearby active and inactive coal mining operations, density of oil and gas operations, and density of roadways were characterized for all HUCs. Poisson regression analyses were used to estimate adjusted prevalence ratios. From 1,459 eligible households contacted, 1,190 individuals were recruited, and 972 persons completed the interviews. The prevalence of lifetime asthma was 22.8%; current asthma was 16.3%. Adjusting for covariates, roadway density was positively associated with current asthma in the second (aPR = 1.61; 95% CI 1.04–2.48) and third tertiles (aPR = 2.00; 95% CI 1.32–3.03). Increased risk of current asthma was associated with residence in public, multi-unit housing (aPR = 2.01; 95% CI 1.27–3.18) compared to a residence in a single-family home. There were no notable associations between proximity to coal mining and oil and gas operations and asthma prevalence. This study suggests that residents in rural areas with higher roadway density and those residing in public housing units may be at increased risk for current asthma after accounting for other known risk factors. Confirming the role of traffic-related particulates in producing high asthma risk among adults in this study contributes to the understanding of the multiple environmental exposures that influence respiratory health in the Appalachia region.
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阿巴拉契亚农村地区吸烟的持续差异：山地空气项目的证据。
影响因子：
4.5
作者：
Cardarelli K;Westneat S;Dunfee M;May B;Schoenberg N;Browning S
通讯作者：
Browning S
影响因子：
1.1
作者：
Christian, W. Jay;Walker, Courtney J.;Hahn, Ellen J.
通讯作者：
Hahn, Ellen J.
影响因子：
4.5
作者：
Lindgren A;Björk J;Stroh E;Jakobsson K
通讯作者：
Jakobsson K
影响因子：
12.7
作者：
Krieger, JW;Takaro, TK;Weaver, M
通讯作者：
Weaver, M
DOI：
10.1007/s00420-008-0328-y
发表时间：
2009-01-01
影响因子：
3
作者：
Hendryx, Michael
通讯作者：
Hendryx, Michael