IMPORTANCE OF DOSE OF NEUTRALIZING ANTIBODIES IN TREATMENT OF ARGENTINE HEMORRHAGIC-FEVER WITH IMMUNE PLASMA
IMPORTANCE OF DOSE OF NEUTRALIZING ANTIBODIES IN TREATMENT OF ARGENTINE HEMORRHAGIC-FEVER WITH IMMUNE PLASMA
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DOI：
10.1016/s0140-6736(84)90299-x
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发表时间：
1984-01-01
期刊：
影响因子：
168.9
通讯作者：
MAIZTEGUI, JI
中科院分区：
文献类型：
--
作者：
ENRIA, DA;BRIGGILER, AM;MAIZTEGUI, JI
在一项回顾性研究中，阿根廷出血热患者的结局与输注单位免疫血浆中存在的抗朱宁病毒中和抗体的量相关。低剂量的中和抗体与较高的死亡率相关。一项前瞻性研究得出了类似的结果。一剂≤推荐每公斤体重3000治疗单位的中和抗体。免疫血浆在治疗其他病毒性出血热（如拉沙热和克里米亚-刚果出血热）方面缺乏有效性，可能是由于低剂量的特异性中和抗体。
In a retrospective study outcome in patients with Argentine hemorrhagic fever was associated with the amount of neutralizing antibodies against Junin virus present in the transfused units of immune plasma. Low doses of neutralizing antibodies were associated with higher mortality. A prospective study gave comparable results. A dose of .ltoreq. 3000 therapeutic units of neutralizing antibodies per kg body weight is recommended. The lack of effectiveness of immune plasma in the treatment of other viral hemorrhagic fevers, such as Lassa fever and Crimean-Congo hemorrhagic fever, may be due to a low dose of the specific neutralizing antibodies.