Dexamethasone and sphingolipids inhibit concanavalin A stimulated glucose uptake in 3T3-L1 fibroblasts.
Dexamethasone and sphingolipids inhibit concanavalin A stimulated glucose uptake in 3T3-L1 fibroblasts.
复制标题
地塞米松和鞘脂抑制伴刀豆球蛋白 A 刺激的 3T3-L1 成纤维细胞的葡萄糖摄取。
DOI：
10.1080/07435808809032992
复制
发表时间：
1988
影响因子：
2.1
通讯作者：
Murray,DK
中科院分区：
文献类型：
--
作者：
Nelson,DH;Murray,DK
在3 T3-L1成纤维细胞中进行研究，以确定鞘脂和皮质类固醇对A刺激的葡萄糖摄取中的concanaval的影响。鞘氨醇（40 μM）和鞘氨醇（40和100 μM）显着抑制伴刀豆球蛋白A刺激的葡萄糖摄取（P<0.025 & <0.005）。预先与10− 7 M地塞米松孵育也显著抑制伴刀豆球蛋白A刺激的葡萄糖摄取（P <0.005）。已知皮质类固醇对鞘脂合成、降解和组织水平的影响表明，皮质类固醇对葡萄糖摄取的抑制可能是通过类固醇对鞘脂代谢的影响。
Studies were carried out in 3T3-L1 fibroblasts to determine the effect of sphingolipids and corticosteroids on concanaval in A stimulated glucose uptake. Sphinganine (40 μM) and sphingosine (40 AND 100 μM) significantly inhibited concanavalin A stimulated glucose uptake (P<0.025 & <0.005). Prior incubation with 10−7M dexamethasone also significantly inhibited concanavalin A stimulated glucose uptake (P <0.005). The known effects of corticosteroids on sphingolipid synthesis, degradation, and tissue levels, suggest inhibition by corticosteroids of glucose uptake may be through effects of the steroid on sphingolipid metabolism.