Immunoglobulin content in the bronchial washings of patients with benign and malignant pulmonary disease.
Immunoglobulin content in the bronchial washings of patients with benign and malignant pulmonary disease.
复制标题
良性和恶性肺部疾病患者支气管洗液中的免疫球蛋白含量。
DOI：
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发表时间：
1976
影响因子：
158.5
通讯作者：
J. Decosse
中科院分区：
文献类型：
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作者：
M. Mandel;K. Dvorak;L. Worman;J. Decosse
对58例肺部良性和肿瘤性疾病患者的支气管冲洗液进行免疫球蛋白含量评价。将来自患病肺的洗涤液中的水平与来自正常对侧肺的洗涤液中的水平进行比较。在正常患者以及患有双侧炎症性疾病、单侧支气管扩张症或结核病的患者中，患病肺和未受累肺之间的伊加/K和igG/K比率的平均变化很小。单侧肺炎组IgG/K明显升高（P <0.01）。癌症患者患侧的伊加/K发生显著变化。在鳞状细胞癌组。平均升高4.6倍（P <0.005），腺癌和未分化癌分别升高6.4倍和2.8倍（P <0.01和P <0.01）。因此，与正常肺相比，癌似乎改变了受影响肺中局部免疫球蛋白的产生。（N Engl J Med 295：694-698，1976）。
The bronchial washings of 58 patients with benign and neoplastic conditions involving the lungs were evaluated for immunoglobulin content. Levels in the washings from the diseased lung were compared with those from the normal contralateral lung. In normal patients and those with either bilateral inflammatory diseases or unilateral bronchiectasis or tuberculosis, the mean variation in igA/K and igG/K ratios between diseased and uninvolved lungs was minimal. In unilateral pneumonitis, however, igG/K was markedly elevated (P less than 0.01). Significant changes in the igA/K occurred on the affected side in patients with cancer. In the group with squamous-cell cancer. the mean elevation was 4.6 times that of contralateral lung (P less than 0.005), whereas with adenocarcinoma and undifferentiated carcinoma, the rise was 6.4 and 2.8 times, respecitvely (P less than 0.01 and P less than 0.01). Thus, carcinoma appears to alter local immunoglobulin production in the affected lung as compared to its normal counterpart. (N Engl J Med 295:694-698, 1976).