Immunoglobulins and immunoglobulin subclasses in the elderly
Immunoglobulins and immunoglobulin subclasses in the elderly
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DOI：
10.1258/000456303763046067
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发表时间：
2003-03-01
影响因子：
2.2
通讯作者：
Unsworth, DJ
中科院分区：
文献类型：
--
作者：
Lock, RJ;Unsworth, DJ
背景已发表的数据表明，成人浓度达到所有IG同种型和高原的15-18岁。然而，最近的数据表明，这些结果不适用于老年人。IgG亚类无等效数据。我们目前的参考范围数据为英国老年患者人群，IgG，伊加，IgM和IgG subclass.Methods血清免疫球蛋白进行了审查，从1146例患者> 60岁，925例患者年龄在18-60岁的样本。对来自498名> 60岁的患者和484名18-60岁的患者的样品进行了血清IgG亚类的审查。通过比浊法测量所有Ig和亚类。结果老年人血清IgG和IgM浓度中位数降低（IgG女性P
Background Published data imply that adult concentrations are achieved for all Ig isotypes and plateau by 15-18 years of age. Recent data, however, suggest that these results are not applicable in the elderly. There are no equivalent data for IgG subclasses. We present reference range data for an elderly UK patient population, for IgG, IgA, IgM and IgG subclasses.Methods Serum immunoglobulins were reviewed on samples from 1146 patients > 60 years of age and 925 patients aged 18-60 years. Serum IgG subclasses were reviewed on samples from 498 patients > 60 years and 484 patients aged 18-60 years. All Igs and subclasses were measured by nephelometry. Reference ranges were derived by probability plotting.Results Serum median IgG and IgM concentrations are reduced in the elderly (IgG female P