Distribution of aerosolized particles in healthy and emphysematous rat lungs: comparison between experimental and numerical studies.
Distribution of aerosolized particles in healthy and emphysematous rat lungs: comparison between experimental and numerical studies.
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DOI：
10.1016/j.jbiomech.2015.01.004
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发表时间：
2015-04-13
影响因子：
2.4
通讯作者：
Vignon-Clementel IE
中科院分区：
文献类型：
--
作者：
Oakes JM;Marsden AL;Grandmont C;Darquenne C;Vignon-Clementel IE
肺部气流和颗粒沉积的计算机模型越来越多地用于确定吸入气溶胶的治疗或毒性作用。尽管计算方法取得了显着进步，但直接将模型预测与实验数据进行比较的研究相对较少。此外，之前很少有研究探讨肺气肿对颗粒沉积的影响。在这项工作中，我们进行了气流和颗粒模拟，以将数值预测与我们之前的气溶胶暴露实验的数据进行比较。采用基于图像的 3D 大鼠气道几何结构，我们首先将健康大鼠肺部的稳态流动模拟与耦合 3D-0D 非稳态模拟进行比较。然后，在 3D-0D 模拟中，通过将疾病位置与实验研究相匹配来研究肺气肿的影响。在健康的非稳态和稳态模拟中，气溶胶输送的数值预测与实验沉积数据之间存在良好的一致性。然而，不稳定和稳定情况下 3D 几何结构中的沉积模式有所不同。相反，对于肺气肿的数值预测和实验数据之间没有发现令人满意的一致性。这表明 3D 几何结构下游的沉积率可能与健康肺部的气流输送成正比，但与肺气肿肺部的气流输送不成正比。包括小气道塌陷、下游气道尺寸和组织特性的变化以及在整个呼气过程中跟踪颗粒可能会在未来的研究中产生更有利的协议。
In silico models of airflow and particle deposition in the lungs are increasingly used to determine the therapeutic or toxic effects of inhaled aerosols. While computational methods have advanced significantly, relatively few studies have directly compared model predictions to experimental data. Furthermore, few prior studies have examined the influence of emphysema on particle deposition. In this work we performed airflow and particle simulations to compare numerical predictions to data from our previous aerosol exposure experiments. Employing an image-based 3D rat airway geometry, we first compared steady flow simulations to coupled 3D-0D unsteady simulations in the healthy rat lung. Then, in 3D-0D simulations, the influence of emphysema was investigated by matching disease location to the experimental study. In both the healthy unsteady and steady simulations, good agreement was found between numerical predictions of aerosol delivery and experimental deposition data. However, deposition patterns in the 3D geometry differed between the unsteady and steady cases. On the contrary, satisfactory agreement was not found between the numerical predictions and experimental data for the emphysematous lungs. This indicates that the deposition rate downstream of the 3D geometry is likely proportional to airflow delivery in the healthy lungs, but not in the emphysematous lungs. Including small airway collapse, variations in downstream airway size and tissue properties, and tracking particles throughout expiration may result in a more favorable agreement in future studies.