Blob Enhancement and Visualization for Improved Intracranial Aneurysm Detection
Blob Enhancement and Visualization for Improved Intracranial Aneurysm Detection
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DOI：
10.1109/tvcg.2015.2446493
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发表时间：
2016-06-01
影响因子：
5.2
通讯作者：
Spiclin, Ziga
中科院分区：
文献类型：
--
作者：
Jerman, Tim;Pernus, Franjo;Spiclin, Ziga
一些研究已经确定，视觉评估较小颅内动脉瘤的灵敏度不令人满意。基于斑点增强过滤器响应的体积渲染的计算机辅助诊断可以通过将诊断医生引导到脑血管系统中的可疑位置来缩短目视检查并提高检测灵敏度。我们提出了一种新的斑点增强滤波器的基础上修改的体积比的海森特征值，具有更均匀的响应内的斑点状结构相比，国家的最先进的过滤器。由于该滤波器的响应与结构的大小和强度无关，因此它对检测小的斑点状结构（如缩略语）特别敏感。我们提出了一种新的体绘制方法，它是敏感的信号能量沿着的视线，并在视觉上增强了可视化的真阳性和抑制通常尖锐的假阳性反应。在动脉瘤患者的合成数据集和42个临床数据集上对所提出的和最先进的方法进行了定量评价。由于能够准确增强动脉瘤的边界，并且由于可视化的假阳性响应数量较少，因此组合使用所提出的过滤器和可视化方法可确保可靠地检测（小型）颅内动脉瘤。
Several researches have established that the sensitivity of visual assessment of smaller intracranial aneurysms is not satisfactory. Computer-aided diagnosis based on volume rendering of the response of blob enhancement filters may shorten visual inspection and increase detection sensitivity by directing a diagnostician to suspicious locations in cerebral vasculature. We proposed a novel blob enhancement filter based on a modified volume ratio of Hessian eigenvalues that has a more uniform response inside the blob-like structures compared to state-of-the-art filters. Because the response of proposed filter is independent of the size and intensity of structures, it is especially sensitive for detecting small blob-like structures such as aneuryms. We proposed a novel volume rendering method, which is sensitive to signal energy along the viewing ray and which visually enhances the visualization of true positives and suppresses usually sharp false positive responses. The proposed and state-of-the-art methods were quantitatively evaluated on a synthetic dataset and 42 clinical datasets of patients with aneurysms. Because of the capability to accurately enhance the aneurysm's boundary and due to a low number of visualized false positive responses, the combined use of the proposed filter and visualization method ensures a reliable detection of (small) intracranial aneurysms.