Cyclomatrix Polyphosphazene Porous Networks with J-Aggregated Multiphthalocyanine Arrays for Dual-Modality Near-Infrared Photosensitizers
Cyclomatrix Polyphosphazene Porous Networks with J-Aggregated Multiphthalocyanine Arrays for Dual-Modality Near-Infrared Photosensitizers
复制标题
用于双模态近红外光敏剂的具有J聚集多酞菁阵列的环基聚磷腈多孔网络
DOI：
10.1021/acsami.8b13594
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Jia Guo
中科院分区：
文献类型：
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作者：
Jing Tan;Jittima Meeprasert;Yuxue Ding;Supawadee Namuangruk;Xuesong Ding;Changchun Wang;Jia Guo
本论文中，我们开发了一种具有优良物理化学性质的环基质聚磷腈，并探索了其作为双模态光疗有机光敏剂的潜力。简单地说，采用具有D3 h对称性的六氯环磷腈（HCCP）作为合成子，连接到锌（II）酞菁（ZnPc）形成树枝状单元，通过亲核取代反应共价扩展成可溶性多孔网络。分子模拟结果表明，HCCP周围的多个ZnPc单元可以并排排列，导致其在近红外（NIR）区的吸收峰明显红移。为了验证其在生物应用中的潜力，通过引入聚乙烯吡咯烷酮（PVP）来组装这种基于ZnPc的聚磷腈，以制备具有水性分散性和生物相容性的均匀纳米颗粒。从体外结果来看，PVP稳定的光敏纳米颗粒可以经历光热/光动力过程，以在暴露于单带宽NIR激光（785 nm）时同时产生热量和单线态氧，从而有效地杀死癌细胞。与已知的有机光敏剂相比，cyclomatrix聚磷腈将是一个有前途的平台，以配置具有密集和定向排列的染料分子的网状阵列的多样性，导致其大大增强的物理和光化学性能。
Here, we have developed a kind of cyclomatrix polyphosphazene with excellent photophysical properties and pursued their potential of being organic photosensitizers for dual-modality phototherapy. Briefly, hexachlorocyclophosphazene (HCCP) withD3hsymmetry is adopted as a synthon to attach Zn(II) phthalocyanine (ZnPc) to form dendritic units that are covalently expanded into a soluble porous network through the nucleophilic substitution reaction. Molecular simulation reveals that the multi-ZnPc units around HCCP can be oriented in a side-by-side manner, leading to the remarkably red-shifted and intense absorbance in the near-infrared (NIR) region. To validate the potential in bioapplication, such ZnPc-based polyphosphazenes are assembled by incorporation of polyvinylpyrrolidone (PVP) to produce the uniform nanoparticles with aqueous dispersibility and biocompatibility. From the in vitro results, the PVP-stabilized photosensitizing nanoparticles can undergo the photothermal/photodynamic processes to concurrently generate heat and singlet oxygen for efficiently killing cancer cells upon exposure to a single-bandwidth NIR laser (785 nm). Compared with the known organic photosensitizers, cyclomatrix polyphosphazene would be a promising platform to configure a diversity of reticular arrays with dense and oriented arrangement of dye molecules, leading to their largely enhanced photophysical and photochemical properties.