Magnetic resonance imaging of mediodorsal, pulvinar, and centromedian nuclei of the thalamus in patients with schizophrenia
Magnetic resonance imaging of mediodorsal, pulvinar, and centromedian nuclei of the thalamus in patients with schizophrenia
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DOI：
10.1001/archpsyc.60.9.983
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发表时间：
2003-10-01
影响因子：
--
通讯作者：
Bloom, R
中科院分区：
文献类型：
--
作者：
Kemether, EM;Buchsbaum, MS;Bloom, R
背景资料：尸检和磁共振成像（MRI）的数据表明，体积减少的背内侧核（MDN）和枕核（PUL）的丘脑。中央中核（CMN），重要的注意力和觉醒，以前没有研究与MRI。方法：41例精神分裂症患者（32名男性和9名女性）和60名健康志愿者（45名男性和15名女性）的样本进行了评估与高分辨率1.2毫米厚的解剖MRI。图像进行了分化，以提高整个丘脑的边缘和轮廓，和MDN，PUL，和CMN概述了所有切片的示踪掩蔽诊断status.Results：显着较小的体积的MDN和PUL被发现在精神分裂症患者与对照组相比。体积相对于脑大小减少，在所有3个核团，相对减少的差异并没有不同的核团。其余的丘脑体积（整个丘脑减去体积的3个划定的核）是没有不同的精神分裂症患者和对照组之间，表明体积减少是特定于这些核。体积相对于大脑大小减少，在所有3个核团，并保持显着时，只有从未接触过神经安定药物的患者（n = 15）被认为是。对于MDN，女性有较大的相对体积比男性之间的控制，但男性有较大的体积比女性精神分裂症patients.Conclusions：三个关联区域的丘脑，有相互连接的精神分裂症相关区域的皮质有显着较小的体积在MRI上的精神分裂症患者。
Background: Postmortem and magnetic resonance imaging (MRI) data have suggested volume reductions in the mediodorsal (MDN) and pulvinar nuclei (PUL) of the thalamus. The centromedian nucleus (CMN), important in attention and arousal, has not been previously studied with MRI.Methods: A sample of 41 patients with schizophrenia (32 men and 9 women) and 60 healthy volunteers (45 men and 15 women) underwent assessment with high-resolution 1.2-mm thick anatomical MRI. Images were differentiated to enhance the edges and outline of the whole thalamus, and the MDN, PUL, and CMN were outlined on all slices by a tracer masked to diagnostic status.Results: Significantly smaller volumes of the MDN and PUL were found in patients with schizophrenia compared with controls. Volume relative to brain size was reduced in all 3 nuclei; differences in relative reduction did not differ among the nuclei. The remainder of the thalamic volume (whole thalamus minus the volume of the 3 delineated nuclei) was not different between schizophrenic patients and controls, indicating that the volume reduction was specific to these nuclei. Volume relative to brain size was reduced in all 3 nuclei and remained significant when only patients who had never been exposed to neuroleptic medication (n = 15) were considered. For the MDN, women had larger relative volumes than men among controls, but men had larger volumes than women among schizophrenic patients.Conclusions: Three association regions of the thalamus that have reciprocal connectivity to schizophrenia-associated regions of the cortex have significantly smaller volumes on MRI in patients with schizophrenia.