NF-κB: At the Borders of Autoimmunity and Inflammation.
NF-κB: At the Borders of Autoimmunity and Inflammation.
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DOI：
10.3389/fimmu.2021.716469
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发表时间：
2021
影响因子：
7.3
通讯作者：
Weil R
中科院分区：
文献类型：
--
作者：
Barnabei L;Laplantine E;Mbongo W;Rieux-Laucat F;Weil R
转录因子NF-κB调节先天免疫和获得性免疫功能的多个方面，是炎症反应的关键介质。在本综述的第一部分中，我们讨论了参与免疫稳态的NF-κB的诱导物、信号通路和调节因子，并详细说明了泛素化对NF-κB功能的翻译后调控的重要性。我们还指出了中枢和外周耐受的阶段，在这些阶段中，核因子-κB发挥了重要作用。在中枢耐受方面，我们详细介绍了核因子-κB如何调节胸腺上皮细胞的发育、稳态和功能。此外，我们详细阐述了它在双阳性(DP)胸腺细胞从胸腺皮质迁移到髓质中的作用。在外周免疫耐受方面，我们概述了NF-κB如何导致自身反应性T和B淋巴细胞的失活和破坏，以及与免疫耐受有关的CD4+-T细胞亚群的分化。在综述的后半部分，我们描述了核因子-κB在自身免疫和自身炎症发病机制中的作用。最近发现的涉及该通路组成部分的突变既加深了我们对自身免疫性疾病的理解，也为治疗这些疾病提供了新的治疗方法。
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory response. In the first part of this review, we discuss the NF-κB inducers, signaling pathways, and regulators involved in immune homeostasis as well as detail the importance of post-translational regulation by ubiquitination in NF-κB function. We also indicate the stages of central and peripheral tolerance where NF-κB plays a fundamental role. With respect to central tolerance, we detail how NF-κB regulates medullary thymic epithelial cell (mTEC) development, homeostasis, and function. Moreover, we elaborate on its role in the migration of double-positive (DP) thymocytes from the thymic cortex to the medulla. With respect to peripheral tolerance, we outline how NF-κB contributes to the inactivation and destruction of autoreactive T and B lymphocytes as well as the differentiation of CD4+-T cell subsets that are implicated in immune tolerance. In the latter half of the review, we describe the contribution of NF-κB to the pathogenesis of autoimmunity and autoinflammation. The recent discovery of mutations involving components of the pathway has both deepened our understanding of autoimmune disease and informed new therapeutic approaches to treat these illnesses.
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影响因子：
30.5
作者：
Chang, Jae-Hoon;Xiao, Yichuan;Hu, Hongbo;Jin, Jin;Yu, Jiayi;Zhou, Xiaofei;Wu, Xuefeng;Johnson, Howard M.;Akira, Shizuo;Pasparakis, Manolis;Cheng, Xuhong;Sun, Shao-Cong
通讯作者：
Sun, Shao-Cong
影响因子：
5.6
作者：
Berlec, Aies;Perse, Martina;Strukelj, Borut
通讯作者：
Strukelj, Borut
影响因子：
6.2
作者：
Caso F;Galozzi P;Costa L;Sfriso P;Cantarini L;Punzi L
通讯作者：
Punzi L
影响因子：
32.4
作者：
Baratin, Myriam;Foray, Chloe;Lawrence, Toby
通讯作者：
Lawrence, Toby
DOI：
10.1056/nejmoa0807865
发表时间：
2009-06-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Aksentijevich I;Masters SL;Ferguson PJ;Dancey P;Frenkel J;van Royen-Kerkhoff A;Laxer R;Tedgård U;Cowen EW;Pham TH;Booty M;Estes JD;Sandler NG;Plass N;Stone DL;Turner ML;Hill S;Butman JA;Schneider R;Babyn P;El-Shanti HI;Pope E;Barron K;Bing X;Laurence A;Lee CC;Chapelle D;Clarke GI;Ohson K;Nicholson M;Gadina M;Yang B;Korman BD;Gregersen PK;van Hagen PM;Hak AE;Huizing M;Rahman P;Douek DC;Remmers EF;Kastner DL;Goldbach-Mansky R
通讯作者：
Goldbach-Mansky R