CHRONIC IDIOPATHIC URTICARIA - PROFILES OF SKIN MAST-CELL HISTAMINE-RELEASE DURING ACTIVE DISEASE AND REMISSION
CHRONIC IDIOPATHIC URTICARIA - PROFILES OF SKIN MAST-CELL HISTAMINE-RELEASE DURING ACTIVE DISEASE AND REMISSION
复制标题
DOI：
10.1016/0091-6749(92)90297-f
复制
发表时间：
1992-06-01
影响因子：
14.2
通讯作者：
HEBERT, J
中科院分区：
文献类型：
--
作者：
JACQUES, P;LAVOIE, A;HEBERT, J
慢性特发性荨麻疹 (CIU) 的特征是正常皮肤中肥大细胞释放组胺的能力增加。在活动性 CIU 中，这种异常始终存在。为了确定当疾病进入缓解期时这种现象是否会消退，我们使用皮室技术分析了缓解期 CIU 患者 (CIUR) 与 CIU 患者和正常对照 (NC) 受试者的组胺分泌情况。在 CIU 和 CIUR 组中，用化合物 48/80 攻击的部位的组胺释放曲线显着不同。此外，CIUR 患者与 NC 受试者在化合物 48/80 刺激下的组胺释放能力方面没有差异 (p > 0.1)。这些数据表明，皮肤肥大细胞过度敏感的状态在CIU疾病中是一种可逆且短暂的现象。
Chronic idiopathic urticaria (CIU) is characterized by the increased releasability of histamine by mast cells in normal-appearing skin. In active CIU, this abnormality is consistently present, To determine if this finding subsides when the disease goes into remission phase, we analyzed the histamine secretion in patients with CIU in remission (CIUR) compared with that of patients with CIU and in normal control (NC) subjects, with the skin-chamber technique. The profiles of histamine release in sites challenged with compound 48/80 were significantly different in the groups with CIU and CIUR. Furthermore, patients with CIUR did not differ from NC subjects in terms of histamine releasability under compound 48/80 stimulation (p > 0.1). These data suggest that the state of excessive skin mast cell sensitivity is a reversible and transient phenomenon in CIU disease.