Serum IL-9 Levels Depend on Allergen Exposure: Preliminary Study
Serum IL-9 Levels Depend on Allergen Exposure: Preliminary Study
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DOI：
10.1159/000321111
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发表时间：
2011-01-01
影响因子：
2.8
通讯作者：
Marseglia, Gianluigi
中科院分区：
文献类型：
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作者：
Ciprandi, Giorgio;De Amici, Mara;Marseglia, Gianluigi
研究背景：Th 9是一种新的T细胞亚群，其特征是产生白细胞介素9（IL-9）。血清IL-9水平与变应性鼻炎（AR）患者的症状严重程度相关。本研究旨在研究IL-9是否依赖于过敏原暴露。研究方法：研究了35例对墙草属单一致敏的AR患者（16例男性，平均年龄33.2岁）的症状;同时招募了38例对桦树非致敏的AR患者（22例男性，平均年龄30.9岁），但无症状。检测血清IL-9水平。结果如下：接触过敏原的墙草过敏患者血清IL-9水平高于未接触过敏原的桦树过敏患者（p < 0.05）。结论：这项初步研究表明，血清IL-9水平可能取决于过敏原暴露：在花粉季节评估的花粉诱导AR的症状性患者，其值高于在花粉季节以外研究的无症状患者。版权所有（C）2010 S. Karger AG，巴塞尔
Background: Th9 is a new T cell subset characterized by interleukin 9 (IL-9) production. Serum IL-9 levels are related to symptom severity in patients with allergic rhinitis (AR). This study aimed at investigating whether IL-9 may depend on allergen exposure. Methods: 35 AR patients (16 males, mean age 33.2 years) with monosensitization to Parietaria were studied when symptomatic; 38 AR patients (22 males, mean age 30.9 years) with nnonosensitization to birch were recruited at the same time, but were symptom free. Serum IL-9 was assayed in all patients. Results: Patients with Parietaria allergy and exposed to allergen had higher serum IL-9 levels than patients with birch allergy and not exposed to allergen (p < 0.05). Conclusions: This preliminary study shows that serum IL-9 levels may depend on allergen exposure: symptomatic patients with pollen-induced AR, evaluated during the pollen season, have higher values than patients studied outside the pollen season and without symptoms. Copyright (C) 2010 S. Karger AG, Basel