Serologic responses of children with meningitis due to Haemophilus influenzae type b.
Serologic responses of children with meningitis due to Haemophilus influenzae type b.
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b 型流感嗜血杆菌所致脑膜炎儿童的血清学反应。
DOI：
10.1093/infdis/134.5.495
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
M. Melish
中科院分区：
文献类型：
--
作者：
C. Norden;R. Michaels;M. Melish
采用杀菌抗体法（BAA）和放射免疫法（RIA）检测抗体，对100例乙型流感嗜血杆菌所致脑膜炎住院患儿的免疫应答进行了测定。短期（发病后14-17天）反应在20名儿童中仅通过RIA检测，在6名儿童中仅通过BAA检测，在23名儿童中同时采用两种检测。更敏感的RIA检测到20名仅使用BAA就会被标记为“免疫无反应”的儿童。抗体反应的强度明显与年龄相关。26例无立即抗体反应的患儿中，11例在2 ~ 20个月后复查时抗体滴度仍未升高；剩下的15例随后滴度增加。两到18个月后，在10名立即表现出抗体反应的儿童中，有9名在额外的血液样本中仍然呈阳性。超过一半的儿童最初对b型流感嗜血杆菌脑膜炎无反应，随后产生特异性抗体。其余患者在疾病急性期或恢复期后期均未获得可检测的抗体，值得进一步调查其对b型流感嗜血杆菌脑膜炎免疫反应低下的性质。
The immunologic responses of 100 children hospitalized with meningitis due to Haemophilus influenzae type b were measured by the bactericidal antibody assay (BAA) and radioimmunoassay (RIA) for detection of antibody. Short-term (14-17 days after onset of illness) responses were detected by RIA alone in 20 children, by BAA alone in six, and by both tests in 23. The more sensitive RIA detected 20 children who would have been labeled "immunologically unresponsive" had only BAA been used. The magnitude of the antibody response was clearly related to age. Of 26 children with no immediate antibody response, 11 still had no rise in titer of antibody when restudied two to 20 months later; the remaining 15 had subsequent increases in titer. Nine of 10 children who showed an immediate antibody response remained positive when additional blood smaples were taken two to 18 months later. Over half of the children initially unresponsive to H. influenzae type b meningitis subsequently developed specific antibodies. The remainder, who failed to acquire detectable antibodies at either the acute stage of illness or late in convalescence, deserve further investigation as to the nature of their immunologic hyporesponsiveness to H. influenzae type b meningitis.