Soy protein intake, carchorenal indices, and C-reactive protein in type 2 diabetes with nephropathy - A longitudinal randomized clinical trial
Soy protein intake, carchorenal indices, and C-reactive protein in type 2 diabetes with nephropathy - A longitudinal randomized clinical trial
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DOI：
10.2337/dc07-2065
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发表时间：
2008-04-01
期刊：
影响因子：
16.2
通讯作者：
Esmaillzadeh, Ahmad
中科院分区：
文献类型：
--
作者：
Azadbakht, Leila;Atabak, Shahnaz;Esmaillzadeh, Ahmad
目的：有几个关于大豆消费对心血管风险影响的短期试验，但关于长期大豆蛋白消费对2型糖尿病肾病患者的影响的证据很少。为了确定长期食用大豆对心血管风险的影响，我们测量了伴有肾病的2型糖尿病患者的c反应蛋白（CRP）和肾功能指标。研究设计和方法：这项纵向随机临床试验在41名2型糖尿病肾病患者中进行（18名男性和23名女性）。大豆蛋白组的20名患者食用含有0.8 g蛋白质/kg体重的饮食（35%动物蛋白，35%纹理大豆蛋白和30%植物蛋白），对照组的21名患者食用含有70%动物蛋白和30%植物蛋白的类似饮食，为期4年。结果：大豆蛋白摄入显著影响心血管风险，如空腹血糖（大豆蛋白与对照组的平均变化：- 18.3 vs. -2 mg/dl, P = 0.03）、总胆固醇（-23 +/- 5 vs. 10 +/- 3 mg/dl, P = 0.01）、低密度脂蛋白胆固醇（-20 +/- 5 vs. 6 +/- 2 mg/dl, P = 0.01）和血清甘油三酯（-24 +/- 6 vs. -5 +/- 2 mg/dl, P = 0.01）浓度。与对照组相比，摄入大豆蛋白显著降低了血清CRP水平（1.31 +/- 0.6 vs. 0.33 +/- 0.1 mg/l; P = 0.02）。蛋白尿（-0.15 +/- 0.03 g/d vs. 0.02 +/- 0.01 g/d; P = 0.001）和尿肌酐(- 1。5±0.9 vs. 0。6 +/- 0.3 mg/dI, P = 0。0.1)通过食用大豆蛋白结论：纵向大豆蛋白摄入显著影响2型糖尿病肾病患者的心血管危险因素和肾脏相关生物标志物。
OBJECTIVE - Several short-term trials on the effect of soy consumption on cardiovascular risks are available, but little evidence exists regarding the impact of long-term soy protein consumption among type 2 diabetic patients with nephropathy. To determine the effects of long-term soy consumption on cardiovascular risks, we measured C-reactive protein (CRP) and kidney function indexes among type 2 diabetic patients with nephropathy.RESEARCH DESIGN AND METHODS - This longitudinal randomized clinical trial was conducted among 41 type 2 diabetic patients with nephropathy (18 men and 23 women). Twenty patients in the soy protein group consumed a diet containing 0.8 g protein/kg body weight (35% animal proteins, 35% textured soy protein, and 30% vegetable proteins) and 21 patients in the control group consumed a similar diet containing 70% animal proteins and 30% vegetable proteins for 4 years.RESULTS - Soy protein consumption significantly affected cardiovascular risks such as fasting plasma glucose (mean change in the soy protein versus control groups: - 18 3 vs. I I - 2 mg/dl; P = 0.03), total cholesterol (-23 +/- 5 vs. 10 +/- 3 mg/dl; P = 0.01), LDL cholesterol (-20 +/- 5 vs. 6 +/- 2 mg/dl; P = 0.01), and serum triglyceride (-24 +/- 6 vs. -5 +/- 2 mg/dl; P = 0.01) concentrations. Serum CRP levels were significantly decreased by soy protein intake compared with those in the control group (1.31 +/- 0.6 vs. 0.33 +/- 0.1 mg/l; P = 0.02). Significant improvements were also seen in proteinuria (-0.15 +/- 0.03 vs. 0.02 +/- 0.01 g/day; P = 0.001) and urinary creatinine (- 1. 5 +/- 0.9 vs. 0. 6 +/- 0.3 mg/dI, P = 0. 0 1) by consumption of soy protein.CONCLUSIONS - Longitudinal soy protein consumption significantly affected cardiovascular risk factors and kidney-related biomarkers among type 2 diabetic patients with nephropathy.