Chloroquine Administration Does Not Prevent Nipah Virus Infection and Disease in Ferrets
Chloroquine Administration Does Not Prevent Nipah Virus Infection and Disease in Ferrets
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DOI：
10.1128/jvi.01847-09
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发表时间：
2009-11-15
影响因子：
5.4
通讯作者：
Wang, Lin-Fa
中科院分区：
文献类型：
--
作者：
Pallister, Jackie;Middleton, Deborah;Wang, Lin-Fa
亨德拉病毒和尼帕病毒是亨德拉病毒属中的两种人畜共患副粘病毒，最近出现并继续在人类和动物中引起散发性疾病暴发。据报道，人类的死亡率高达75%，但目前还没有临床许可的治疗方法用于治疗亨尼帕病毒诱导的疾病。最近的一份报告指出，70多年来用于疟疾治疗的氯喹在体外可预防尼帕病毒感染。使用致死性尼帕病毒感染的雪貂模型评估氯喹，发现其对体内尼帕病毒感染无效。
Hendra virus and Nipah virus, two zoonotic paramyxoviruses in the genus Henipavirus, have recently emerged and continue to cause sporadic disease outbreaks in humans and animals. Mortality rates of up to 75% have been reported in humans, but there are presently no clinically licensed therapeutics for treating henipavirus-induced disease. A recent report indicated that chloroquine, used in malaria therapy for over 70 years, prevented infection with Nipah virus in vitro. Chloroquine was assessed using a ferret model of lethal Nipah virus infection and found to be ineffective against Nipah virus infection in vivo.