Dietary quercetin intake and risk of gastric cancer: results from a population-based study in Sweden
Dietary quercetin intake and risk of gastric cancer: results from a population-based study in Sweden
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DOI：
10.1093/annonc/mdq390
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发表时间：
2011-02-01
影响因子：
50.5
通讯作者：
Bellocco, R.
中科院分区：
文献类型：
--
作者：
Ekstrom, A. M.;Serafini, M.;Bellocco, R.
背景资料：研究饮食中抗氧化剂槲皮素对胃癌风险的影响。患者和方法：使用来自瑞典一项大型胃癌病例对照研究的数据（505例患者和1116例对照），我们研究了槲皮素与解剖性心脏病风险之间的关系。（贲门/非贲门）和组织学（肠型和弥漫型）胃癌亚型。我们发现槲皮素与非贲门胃腺癌风险之间存在强负相关，调整后的优势比（OR）为0.57（95%置信区间0.40-0.83）（>= 11.9 mg）每日槲皮素摄入量相对于最低五分位摄入量（< 4 mg槲皮素/天），由显著降低的线性趋势支持（P值< 0.001）。对于肠道和弥漫性亚型也观察到类似的发现。对于贲门癌，我们发现了一个不太明显和不显著的反比关系。槲皮素对女性吸烟者的保护作用似乎更强，在五分位数3-5（> 6 mg槲皮素/天）中，OR值< 0.2。结论：高膳食槲皮素摄入量与非贲门胃腺癌的风险呈负相关，对暴露于氧化应激（如吸烟）的女性的保护作用似乎特别强。
Background: To study the impact of the dietary antioxidant quercetin on risk of gastric adenocarcinoma.Patients and methods: Using data from a large Swedish population-based case-control study of gastric cancer (505 cases and 1116 controls), we studied the association between quercetin and risk of anatomic (cardia/noncardia) and histological (intestinal and diffuse) subtypes of gastric cancer.Results: We found strong inverse associations between quercetin and the risk of noncardia gastric adenocarcinoma, with an adjusted odds ratio (OR) of 0.57 (95% confidence interval 0.40-0.83) for the highest quintile (>= 11.9 mg) of daily quercetin intake relative to the lowest quintile of intake (< 4 mg quercetin/day), supported by a significant decreasing linear trend (P value < 0.001). Similar findings were observed for the intestinal and diffuse subtype. For cardia cancer, we found a less evident and nonsignificant inverse relationship. The protection of quercetin appeared to be stronger among female smokers, with the OR leveled of at values < 0.2 in quintiles 3-5 (> 6 mg quercetin/day).Conclusions: High dietary quercetin intake is inversely related to the risk of noncardia gastric adenocarcinoma, and the protection appears to be particularly strong for women exposed to oxidative stress, such as tobacco smoking.