Endocrine-disrupting chemicals and epigenetic reprogramming in developmental origin of uterine fibroids.
Endocrine-disrupting chemicals and epigenetic reprogramming in developmental origin of uterine fibroids.
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DOI：
10.1177/00368504231215601
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发表时间：
2023-10
期刊：
影响因子：
2.1
通讯作者：
Al-Hendy, Ayman
中科院分区：
文献类型：
--
作者：
Yang, Qiwei;Ali, Mohamed;Bariani, Maria Victoria;Vafaei, Somayeh;Al-Hendy, Ayman
关键词：
内分泌干扰物(EDCs)是一类外源性物质，模拟体内荷尔蒙的影响，导致荷尔蒙失调，导致各种疾病。表观基因组调控已成为维持健康和疾病中器官功能的重要机制。解剖表观基因组和由此产生的基因表达变化提供了对染色质状态的前所未有的洞察，染色质状态强调了疾病的发展，并形成了风险和表型可塑性对环境和内部线索的反应。尖端的高通量技术为理解疾病的病因提供了新的途径，并在更好地治疗和预防疾病的前景光明的道路上找到了新的立足点。我们最近发现，子宫肌层干细胞(MMSCs)是UF的细胞来源，是发育中EDC暴露的目标。多组学方法鉴定的EDC诱导的MMSCs的表观遗传学改变包括DNA甲基化和由DNA甲基转移酶和MLL1调控的组蛋白修饰，这表征了激素依赖型UF中EDC相关风险的分子机制。未来的研究需要确定现实生活中暴露于EDC及其对人类疾病发展和跨代表观遗传的影响之间的联系，这可以帮助探索可能防止与EDC暴露相关的不良后果的策略。
Endocrine-disrupting chemicals (EDCs) are a class of exogenous substances that mimic the effects of hormones in the body, inducing hormonal dysregulation and contributing to various disorders. Epigenome regulation has emerged as an important mechanism for maintaining organ function in health and disease. Dissecting epigenomic and resultant gene expression changes provides unprecedented insight into the chromatin state, which underlines disease development and shapes risk and phenotypic plasticity in response to the environment and internal cues. The cutting-edge, high throughput technologies provide new routes to understanding the etiology of disease and new footholds on the promising path to better treatment and disease prevention. We have recently revealed that myometrial stem cells (MMSCs), the cell origin of UFs, are the target of developmental EDC exposure. The EDC-induced epigenetic changes in MMSCs identified by multi-omics approaches include DNA methylation and histone modification modulated by DNA methyltransferases and MLL1, which characterized the molecular mechanism underlying EDC-related risk in hormone-dependent UFs. Future studies are needed to determine the link between real-life exposures to EDCs and their impact on the development of human diseases and transgenerational epigenetic inheritance, which can help explore strategies that may prevent adverse outcomes linked to EDC exposure.
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影响因子：
5.6
作者：
Hu WY;Hu DP;Xie L;Nonn L;Lu R;Abern M;Shioda T;Prins GS
通讯作者：
Prins GS
影响因子：
3.7
作者：
Ono M;Qiang W;Serna VA;Yin P;Coon JS 5th;Navarro A;Monsivais D;Kakinuma T;Dyson M;Druschitz S;Unno K;Kurita T;Bulun SE
通讯作者：
Bulun SE
DOI：
10.1073/pnas.2208886119
发表时间：
2022-11-22
影响因子：
11.1
作者：
通讯作者：
--
DOI：
10.1097/med.0000000000000578
发表时间：
2020-12
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Bariani MV;Rangaswamy R;Siblini H;Yang Q;Al-Hendy A;Zota AR
通讯作者：
Zota AR
影响因子：
8
作者：
Yang, Qiwei;Ali, Mohamed;Trevino, Lindsey S.;Mas, Aymara;Al-Hendy, Ayman
通讯作者：
Al-Hendy, Ayman