Water may cure patients with Meniere disease
Water may cure patients with Meniere disease
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DOI：
10.1097/01.mlg.0000225904.78569.0c
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发表时间：
2006-08-01
期刊：
影响因子：
2.6
通讯作者：
Okamoto, Makito
中科院分区：
文献类型：
--
作者：
Naganuma, Hideaki;Kawahara, Katsumasa;Okamoto, Makito
目标/假设：我们研究了是否足够的水摄入量是有效的长期控制眩晕和听力活动的梅尼埃病（MD）患者的常规治疗已被证明是不成功的。研究设计：作者进行了一项具有历史对照的时间序列研究。方法：第1组18例AID患者每天饮水35 mL/kg，连续2年。29例MD患者在1992年至1999年期间在同一医院接受常规饮食和利尿治疗超过2年，被纳入历史对照组2。结果在研究期的最后6个月，I组患者的眩晕症状明显缓解，三个频率（0.125、0.25和0.5 kHz）（低PTA）的最差纯音平均听力显著改善。相比之下，第2组的患者在四（0.5，1，2和4 kHz）频率PTA和低PTA中变得更糟，尽管他们的眩晕确实有所改善。听力改善、无变化和恶化的患者数量分别为4例、12例和2例，分别为11例和16例。结论：有意识地调节饮水量可能是MD患者最简单和最具成本效益的医疗方法。需要更大规模的研究来证实这些结果。
Objectives/Hypothesis: We examined whether sufficient water intake is effective in the long-term control of vertigo and hearing activity in patients with Meniere disease (MD) for whom conventional therapy has proven unsuccessful. Study Design: The authors conducted a time-series study with historical control. Methods: Eighteen patients with AID in group 1 drank 35 mL/kg per day of water for 2 years. Twenty-nine patients with MD treated with the conventional dietary and diuretic therapy for more than 2 years during 1992 to 1999 at the same hospital were enrolled in a historical control of group 2. Results. Patients in group I dramatically relieved vertigo and significantly improved in the hearing of the worst pure-tone average of three frequencies (0.125, 0.25, and 0.5 kHz) (low PTA) during the last 6 months of the study period. In contrast, patients in group 2 became worse in both the four- (0.5, 1, 2, and 4 kHz) frequency PTA and the low PTA, although their vertigo did improve. The number of patients whose hearing were improved, unchanged, and worse were 4,12, and 2 in group 1 and 2, 11, and 16 in group 2, respectively. Conclusion: Deliberate modulation of the intake of water may be the simplest and most cost-effective medical treatment for patients with MD. Larger studies will be needed to confirm these results in a larger patient cohort.