More hippocampal neurons in adult mice living in an enriched environment
More hippocampal neurons in adult mice living in an enriched environment
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DOI：
10.1038/386493a0
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发表时间：
1997-04-03
期刊：
影响因子：
64.8
通讯作者：
Gage, FH
中科院分区：
文献类型：
--
作者：
Kempermann, G;Kuhn, HG;Gage, FH
在啮齿动物的整个生命过程中，海马齿状回中都会发生神经发生（1-4），但这些新神经元的功能和调节其出生的机制尚不清楚。在这里，我们表明，与标准笼中的同窝仔相比，暴露于丰富环境的小鼠齿状回中存在更多的新神经元。我们还表明，使用无偏体视学，丰富的小鼠有一个更大的海马颗粒细胞层和15%以上的颗粒细胞神经元在齿状回。
Neurogenesis occurs in the dentate gyrus of the hippocampus throughout the life of a rodent(1-4), but the function of these new neurons and the mechanisms that regulate their birth are unknown, Here we show that significantly more new neurons exist in the dentate gyrus of mice exposed to an enriched environment compared with littermates housed in standard cages. We also show, using unbiased stereology, that the enriched mice have a larger hippocampal granule cell layer and 15 per cent more granule cell neurons in the dentate gyrus.