Concentration of Nicotine and Glycols in 27 Electronic Cigarette Formulations
Concentration of Nicotine and Glycols in 27 Electronic Cigarette Formulations
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DOI：
10.1093/jat/bkw037
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发表时间：
2016-07-01
影响因子：
2.5
通讯作者：
Poklis, Alphonse
中科院分区：
文献类型：
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作者：
Peace, Michelle R.;Baird, Tyson R.;Poklis, Alphonse
开发了个人电池供电的蒸发器或电子香烟以递送尼古丁蒸汽，使得吸烟者可以模拟吸烟烟草，而没有吸入烟草烟雾的固有病理。电子烟及其电子烟液体配方几乎不受监管。这些制剂通常由丙二醇和/或甘油、调味组分和活性药物（例如尼古丁）组成。在美国获得了27种尼古丁含量在6至22 mg/L之间的电子烟液体配方，并通过各种方法进行分析以确定其含量。通过真实的时间直接分析（TM）质谱法（DART-MS）对它们进行筛选。尼古丁通过高效液相色谱-串联质谱法进行确认和定量，乙二醇成分通过气相色谱-质谱法进行确认和定量。DART-MS筛选方法能够在5 mmu内一致地鉴定由尼古丁、乙二醇和多种风味添加剂的质子化分子离子产生的精确质量峰。尼古丁浓度范围为标示浓度的45%至131%，27个样本中有18个样本的差异> 10%。二醇组成通常与产品描述准确一致，只有一个例外，其中丙二醇与甘油的百分比为50：50，丙二醇与甘油的测定浓度为81：19（% v/v）。在这些制剂中未检测到未标记的二醇。
Personal battery-powered vaporizers or electronic cigarettes were developed to deliver a nicotine vapor such that smokers could simulate smoking tobacco without the inherent pathology of inhaled tobacco smoke. Electronic cigarettes and their e-cigarette liquid formulations are virtually unregulated. These formulations are typically composed of propylene glycol and/or glycerin, flavoring components and an active drug, such as nicotine. Twenty-seven e-cigarette liquid formulations that contain nicotine between 6 and 22 mg/L were acquired within the USA and analyzed by various methods to determine their contents. They were screened by Direct Analysis in Real Time (TM) Mass Spectrometry (DART-MS). Nicotine was confirmed and quantitated by high-performance liquid chromatography-tandem mass spectrometry, and the glycol composition was confirmed and quantitated by gas chromatography-mass spectrometry. The DART-MS screening method was able to consistently identify the exact mass peaks resulting from the protonated molecular ion of nicotine, glycol and a number of flavor additives within 5 mmu. Nicotine concentrations were determined to range from 45 to 131% of the stated label concentration, with 18 of the 27 have > 10% variance. Glycol composition was generally accurate to the product description, with only one exception where the propylene glycol to glycerin percentage ratio was stated as 50:50 and the determined concentration of propylene glycol to glycerin was 81:19 (% v/v). No unlabeled glycols were detected in these formulations.