Relationship between infectious gastroenteritis and irritable bowel syndrome.
Relationship between infectious gastroenteritis and irritable bowel syndrome.
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传染性胃肠炎与肠易激综合征之间的关系。
DOI：
10.1007/s12328-013-0444-4
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发表时间：
2014
影响因子：
1
通讯作者：
Fukudo S.
中科院分区：
文献类型：
--
作者：
Kanazawa M;Fukudo S.
一个新认识的致病因素在一个子集的患者肠易激综合征（IBS）被称为感染后IBS（PI-IBS）。肠易激综合征的症状经常在急性传染性胃肠炎发作后出现。在我们对PI-IBS概念的理解中已经进行了几项研究。近年来的研究表明，短暂或慢性胃肠道炎症可能在IBS的发病机制中发挥作用。PI-IBS可以被认为是一种自然的实验模型，其中感染性疾病形式的损伤影响具有潜在遗传和心理社会倾向的受试者，然后发展为IBS。IBS可能是一种复杂的性状，其中临床表现的变异性部分由PI-IBS的潜在遗传和环境风险因素的异质性解释。需要对PI-IBS进行进一步研究，以了解功能性胃肠疾病的病理生理学，并为此类患者开发新的有前途的治疗方法。
A newly recognized causative factor in a subset of patients with irritable bowel syndrome (IBS) is called post-infectious IBS (PI-IBS). IBS symptoms frequently develop after an acute episode of infectious gastroenteritis. Several studies have been made in our understanding of the concept of PI-IBS. Recent studies suggest that transient or chronic gastrointestinal inflammation may play a role in IBS pathogenesis. PI-IBS can be regarded as a natural experiment model in which an insult in the form of an infective disease impacts on subjects with underlying genetic and psychosocial predispositions who then develop IBS. IBS is likely to be a complex trait wherein variability in clinical presentation is partially explained by heterogeneity in underlying genetic and environmental risk factors for PI-IBS. Further studies on PI-IBS are needed to understand the pathophysiology of functional gastrointestinal disorders and to develop new promising management for such patients.