Compound tests for the detection of hitchhiking under positive selection
Compound tests for the detection of hitchhiking under positive selection
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用于检测正选择下搭便车的复合测试。
DOI：
10.1093/molbev/msm119
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发表时间：
2007-08-01
影响因子：
10.7
通讯作者：
Wut, Chung-I
中科院分区：
文献类型：
--
作者：
Zeng, Kai;Shi, Suhua;Wut, Chung-I
已经开发了许多统计检验来检测正选择。大多数这些测试得出的结论与中性模型预测的多态性模式有很大的偏差。然而，许多非平衡力可能导致类似的偏差，因此测试通常对正选择的统计特异性较低。因此，主要的挑战是构建测试统计，它在检测正选择方面相当强大，但对其他力相对不敏感。最近，Zeng et al.（2006）提出了一种新的检验DH，它是Tajima的D和Fay和Wu的H的化合物，并表明DH对阳性选择具有相当高的统计特异性。在本报告中，我们将Fay和Wu的H或DH与Ewens-Watterson （EW）检验相结合，扩展了复合检验的概念。我们将这两个新测试分别称为HEW和DHEW。与DH测试相比，HEW和DHEW测试对重组的存在更加稳健，并且在检测阳性选择方面也更强大。此外，DHEW测试与DH类似，对背景选择和人口统计学也相对不敏感。另一方面，HEW测试在某些情况下往往比DH和DHEW更不保守。
Many statistical tests have been developed for detecting positive selection. Most of these tests draw conclusions based on significant deviations from the patterns of polymorphism predicted by the neutral model. However, many non-equilibrium forces may cause similar deviations, and thus the tests usually have low statistical specificity to positive selection. The main challenge is hence to construct test statistics that are reasonably powerful in detecting positive selection, but are relatively insensitive to other forces. Recently, Zeng et al. (2006) proposed a new test, DH, which is a compound of Tajima's D and Fay and Wu's H, and showed that DH has reasonably high statistical specificity to positive selection. In this report, we expand the idea of a compound test by combining Fay and Wu's H or DH with the Ewens-Watterson (EW) test. We refer to these 2 new tests as HEW and DHEW, respectively. Compared to the DH test, HEW and DHEW are more robust against the presence of recombination, and are also more powerful in detecting positive selection. Furthermore, the DHEW test, similar to DH, is also relatively insensitive to background selection and demography. The HEW test, on the other hand, tends to be somewhat less conservative than DH and DHEW in some cases.