On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination
On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination
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DOI：
10.1063/5.0062787
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发表时间：
2021-08-02
影响因子：
4
通讯作者：
Short, Robert D.
中科院分区：
文献类型：
--
作者：
Szili, Endre J.;Ghimire, Bhagirath;Short, Robert D.
抗生素通常被用作治疗感染性疾病的第一道防线。然而，抗生素耐药性（AMR）的增加使许多抗生素的有效性降低。因此，迫切需要有效的非抗生素抗菌策略来对抗AMR。本文提出了一种策略，利用冷等离子体的“按需”激活乙酰供体分子。所述方法产生水基抗微生物制剂，其包含高氧化性分子的丰富混合物：过乙酸、过氧化氢和其它活性氧和氮物质。这些分子之间的协同有效的氧化作用被证明在根除常见的伤口致病菌（铜绿假单胞菌和金黄色葡萄球菌）和灭活病毒（SARS-CoV-2）方面非常有效。由AIP Publishing独家授权出版。
Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective non-antibiotic antimicrobial strategies are urgently needed to combat AMR. This paper presents a strategy utilizing cold plasma for the "on-demand" activation of acetyl donor molecules. The process generates an aqueous-based antimicrobial formulation comprising a rich mixture of highly oxidizing molecules: peracetic acid, hydrogen peroxide, and other reactive oxygen and nitrogen species. The synergistic potent oxidative action between these molecules is shown to be highly effective at eradicating common wound pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and at inactivating a virus (SARS-CoV-2). Published under an exclusive license by AIP Publishing.