Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci.
Cell proliferation and promotion of rat liver carcinogenesis: different effect of hepatic regeneration and mitogen induced hyperplasia on the development of enzyme-altered foci.
复制标题
细胞增殖和促进大鼠肝癌发生：肝再生和丝裂原诱导的增生对酶改变病灶发展的不同影响。
DOI：
10.1093/carcin/11.5.771
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发表时间：
1990
期刊：
影响因子：
4.7
通讯作者：
Pani,P
中科院分区：
文献类型：
--
作者：
Columbano,A;Ledda-Columbano,GM;Ennas,MG;Curto,M;Chelo,A;Pani,P
A series of experiments was performed to investigate the effect of different types of cell proliferation on the development of enzyme-altered preneoplastic hepatic foci in male Wistar rats. Animals were given a single dose of diethylnitrosamine (100 mg/kg body weight). After a 2-week recovery period liver cell proliferation was repeatedly induced by four or eight necrogenic doses of carbon tetrachloride (compensatory cell proliferation), or by four or eight treatments with three different liver mitogens, namely lead nitrate, ethylene dibromide and nafenopin (direct hyperplasia). The carcinogen altered hepatocytes were monitored as -γ-glutamyltransferase positive or adenosine triphosphatase negative foci. The results indicate that compensatory cell proliferation induced by both four and eight carbon tetrachloride treatments enhanced the growth of diethylnitrosamine-initlated hepatocytes to enzyme- altered foci. On the contrary, repeated waves of cell prolifera tion induced by liver mitogens did not result in any significant number of enzyme-altered foci.
