Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.
Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.
复制标题
表现为克隆性浆细胞成分的套细胞淋巴瘤的分子特征。
DOI：
10.1097/pas.0b013e3182049a9c
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Olse
中科院分区：
文献类型：
--
作者：
Visco,Carlo;Hoeller,Sylvia;Malik,JeffreyT;Xu-Monette,ZijunY;Wiggins,MicheleL;Liu,Jessica;Sanger,WarrenG;Liu,Zhongfeng;Chang,Julie;Ranheim,ErikA;Gradowski,JoelF;Serrano,Sergio;Wang,Huan-You;Liu,Qingquan;Dave,Sandeep;Olse
The normal counterparts of mantle cell lymphoma (MCL) are naive, quiescent B cells that have not been processed through the germinal center (GC). For this reason, although lymphomas arising from GC or post-GC B cells often exhibit plasmacytic differentiation, MCL rarely presents with plasmacytic features. Seven cases of MCL with a monotypic plasma cell (PC) population were collected from 6 centers and were studied by immunohistochemistry, fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms analysis, capillary gel electrophoresis, and restriction fragment length polymorphism of immunoglobulin heavy chain analysis of microdissections of each of the MCL and PC populations to assess their clonal relationship. The clinical presentation was rather unusual compared with typical MCL, with 2 cases arising from the extranodal soft tissues of the head. All MCL cases were morphologically and immunohistochemically typical, bearing the t (11; 14)(q13; q32). In all cases, the PC population was clonal. In 5 of the 7 cases, the MCL and PC clones showed identical restriction fragments, indicating a common clonal origin of the neoplastic population. The 2 cases with clonal diversity denoted the coexistence of 2 different tumors in a composite lymphoma/PC neoplasm. Our findings suggest that MCL can present with a PC component that is often clonally related to the lymphoma, representing a rare but unique biological variant of this tumor.
