Computational methods for the prediction of protein interactions
Computational methods for the prediction of protein interactions
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DOI：
10.1016/s0959-440x(02)00333-0
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发表时间：
2002-06-01
影响因子：
6.8
通讯作者：
Pazos, F
中科院分区：
文献类型：
--
作者：
Valencia, A;Pazos, F
建立蛋白质相互作用网络对于理解细胞运作至关重要。详细的知识的“相互作用组”，蛋白质-蛋白质相互作用的完整网络，在模型细胞系统中应该提供新的见解，这些系统的结构和性能。与实验技术首次大规模应用于蛋白质相互作用网络和蛋白质复合物的测定相平行，第一个基于序列和基因组信息的计算方法已经出现。
Establishing protein interaction networks is crucial for understanding cellular operations. Detailed knowledge of the 'interactome', the full network of protein-protein interactions, in model cellular systems should provide new insights into the structure and properties of these systems. Parallel to the first massive application of experimental techniques to the determination of protein interaction networks and protein complexes, the first computational methods, based on sequence and genomic information, have emerged.