Rational Design of Sequestering Agents for Plutonium and Other Actinides
Rational Design of Sequestering Agents for Plutonium and Other Actinides
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DOI：
10.1002/chin.200405275
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发表时间：
2004-02
期刊：
影响因子：
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通讯作者：
A. Gorden;Jide Xu;K. Raymond;P. Durbin
中科院分区：
文献类型：
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作者：
A. Gorden;Jide Xu;K. Raymond;P. Durbin
提供有效的螯合疗法来应对人体内的鳗系元素污染，已被证明可以减少急性辐射损伤、化学毒性和晚期辐射效应。最近在配位化学的几个领域中的一系列工作的基础上，有可能用于螯合治疗的改进的榄系元素隔离剂的发展。其中的关键是扩大了我们对吖系元素的结构和溶液(热力学)配位的基本理解。这一理解使得镧系金属离子可以被用来作为适合的模型来研究放线元素。这项工作概述了一种设计和优化光化试剂的方法。这一合理的设计方法是为了设计预先组织的多齿光化试剂，其灵感来自于铁载体，这是一种自然产生的微生物铁(III)固着剂。对这些配体的有效性和毒性的生物学评价为正在进行的配体优化过程提供了全面的数据。这使得一类有前景的高选择性体内络合Pu(IV)试剂的开发成为可能。此外，还发现了几种低毒的含儿茶酚或羟基吡啶酸酯结合基团的亚戊二烯或乙醚骨架的四齿线状配体，它们可以与其他的吖系元素进行络合，并已被确定为适合于体内螯合Am(III)、Np(IV/V)或U(VI)的试剂。
Providing effective chelation therapy in response to internal human actinide contamination has been shown to reduce acute radiation damage, chemical toxicity, and late radiation effects. The recent development of improved actinide-sequestering agents for potential use in chelation therapy has been based on a body of work in several areas of coordination chemistry. Key among these is the expansion of our fundamental understanding of the structural and solution (thermodynamics) coordination of the actinides. This understanding allows lanthanide metal ions to be used as suitable models for the actinides. Described in this work is an overview of an approach toward the design and optimization of actinidesequestering agents.This rational approach for the design of preorganized multidentate sequestering agents for actinides was inspired by siderophores, the naturally occurring microbial iron (III)-sequestering agents. Biological evaluation of the efficacy and toxicity of these ligands has provided comprehensive data for the ongoing ligand optimization process. This has enabled the development of a class of promising highly selective agents for in vivo chelation of Pu (IV). In addition, several low-toxicity tetradentate linear ligands with a pentylene or diethyl ether backbones containing catecholate or hydroxypyridinonate binding groups have been found to chelate other actinides and have been identified as suitable agents for in vivo chelation of Am (III), Np (IV/V), or U (VI).