Rising incidence of prostate cancer in Scotland: increased risk or increased detection?
Rising incidence of prostate cancer in Scotland: increased risk or increased detection?
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DOI：
10.1046/j.1464-410x.2000.00487.x
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发表时间：
2000-03-01
影响因子：
4.5
通讯作者：
Black, RJ
中科院分区：
文献类型：
--
作者：
Brewster, DH;Fraser, LA;Black, RJ
目的评估在何种程度上可以解释增加的检测，特别是通过经尿道前列腺切除术（TURP）和使用的前列腺特异性抗原（PSA）test.Subjects和方法这一人群为基础的研究仅限于居住在苏格兰的男性，年龄大于或等于50岁。在1981-1996年期间，研究了年龄特异性和年龄标准化发病率、死亡率和TURF率以及PSA检测率的时间趋势。还分析了1984-1986年（PSA检测前）和1994-1996年（PSA检测后）两个不同时期年龄标准化发病率和死亡率的地理差异。结果≥ 50岁男性前列腺癌的年龄标化率从1981年的142.0/10万上升到1996年的240.9/10万，1992年至1993年增长最快。死亡率在1993年之前也同样上升，但此后相对稳定，1996年略有下降。1981-1988年，TURF发病率与TURF发病率密切相关（r=0.98，P
Objective To assess the extent to which the increasing incidence of prostate cancer in Scotland can be explained by increased detection, particularly through transurethral resection of the prostate (TURP) and use of the prostate-specific antigen (PSA) test.Subjects and methods This population-based study was confined to men resident in Scotland and aged greater than or equal to 50 years. Temporal trends were examined in age-specific and age-standardized incidence, mortality and TURF rates, and PSA testing rates during 1981-1996. Also analysed were the geographical variations in age-standardized incidence and mortality rates during two distinct periods, 1984-1986 (before PSA testing) and 1994-1996 (after PSA testing). Finally, incidence rates and relative survival at 5 years were calculated by age group and 5-year periods of diagnosis during 1968-1992.Results The incidence of prostate cancer in men aged greater than or equal to 50 years increased from an age-standardized rate of 142.0 per 100 000 in 1981 to 240.9 in 1996, with the steepest increase occurring between 1992 and 1993. The mortality rate increased similarly until 1993, but was relatively stable thereafter, falling slightly in 1996. In 1981-1988, incidence rates were closely correlated with TURF rates (r=0.98, P