Bell's Palsy After 24 Hours of mRNA-1273 SARS-CoV-2 Vaccine.
Bell's Palsy After 24 Hours of mRNA-1273 SARS-CoV-2 Vaccine.
复制标题
DOI：
10.7759/cureus.15935
复制
发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Bashir K
中科院分区：
文献类型：
--
作者：
Iftikhar H;Noor SMU;Masood M;Bashir K
2019冠状病毒病（COVID-19）已成为21世纪传播最快的大流行病。通过紧急使用授权提供了各种疫苗。目前，国际上有两种mRNA疫苗，BNT 162 b2和mRNA-1273。在这些疫苗的随机试验中，接种疫苗组的贝尔麻痹发生率在统计学上并没有超过安慰剂组。FDA建议加强对贝尔麻痹的监测，这是全球更大人群接种疫苗的潜在副作用。有一些与mRNA疫苗相关的贝尔麻痹病例报告。I型干扰素被认为是将mRNA COVID-19疫苗与贝尔麻痹联系起来的潜在机制。在这里，我们报告的情况下，一个36岁的以前健康的病人谁开发的贝尔麻痹的症状沿着左臂麻木，刺痛，主观无力伪装成亚急性中风后，接受第二剂的mRNA-1273疫苗。脑部CT和MRI无异常。他出院回家，诊断为贝尔麻痹，并改善了后续行动。mRNA COVID-19疫苗可能被认为是贝尔麻痹的一个风险因素。
Coronavirus disease 2019 (COVID-19) has become the fastest-spreading pandemic of the 21st century. Various vaccines have been made available via emergency use authorization. Currently, two mRNA vaccines are being offered internationally, BNT162b2 and mRNA-1273. In randomized trials of these vaccines, the incidence of Bell’s palsy in the vaccinated group does not statistically exceed the placebo group. The FDA recommends increased surveillance for Bell’s palsy as a potential side effect with the administration of the vaccines among larger populations globally. There have been a few case reports of Bell’s palsy associated with mRNA vaccines. Type I interferons have been proposed as the potential mechanism linking mRNA COVID-19 vaccines to Bell’s palsy. Here, we report the case of a 36-year-old previously healthy patient who developed symptoms of Bell’s palsy along with left-arm numbness, tingling, and subjective weakness masquerading as a subacute stroke after receiving the second dose of the mRNA-1273 vaccine. CT and MRI of the brain were unremarkable. He was discharged home with a diagnosis of Bell’s palsy and improved on follow-up. mRNA COVID-19 vaccines may be considered a risk factor for Bell’s palsy.