Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis.
Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis.
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DOI：
10.1016/j.cyto.2009.07.004
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发表时间：
2009-12
期刊：
影响因子：
3.8
通讯作者：
Ramana, Kota V.
中科院分区：
文献类型：
--
作者：
Reddy, Aramati B. M.;Srivastava, Satish K.;Ramana, Kota V.
严重的全身性感染引起的氧化应激导致血清和组织中细胞因子和趋化因子的产生增加是脓毒症的主要原因。已知醛糖还原酶（AR）介导氧化应激诱导的NF-κB活化以及细胞因子和趋化因子的转录，是细菌内毒素和脂多糖诱导的炎性细胞因子的主要介质。我们的目的是研究AR抑制剂对预防盲肠结扎穿孔（CLP）模型中的炎症细胞因子的影响，该模型非常类似于人类的脓毒症综合征。在不存在和存在AR抑制剂sorbinil的情况下，通过CLP使小鼠脓毒症。Sorbinil可显著抑制小鼠血浆、腹腔液和心脏中细胞因子、趋化因子和其他炎症标志物的水平。抑制AR也可抑制CLP诱导的心、肾和脾组织中的考克斯-2、iNOS和HMGB-1。我们的研究结果表明，AR的抑制显着防止多微生物败血症诱导的炎症标志物的增加，从而表明AR抑制剂作为抗炎剂的用途。
Increased production of cytokines and chemokines in serum and tissues upon oxidative stress caused by severe systemic infections are the major cause of sepsis. Aldose reductase (AR) known to mediate oxidative stress- induced NF-κB activation and transcription of cytokines and chemokines are the main mediator of bacterial endotoxin - and lipopolysaccharide -induced inflammatory cytokines. Our aim is to investigate the effect of AR inhibitors on the prevention of inflammatory cytokines in the cecal ligation and puncture (CLP) model of polymicrobial sepsis which closely mimics the sepsis syndrome in humans. Mice were rendered septic by CLP in the absence and presence of AR inhibitor, sorbinil. The levels of cytokines, chemokines and other inflammatory markers in the plasma, peritoneal fluid and heart of mice were significantly inhibited by sorbinil. Inhibition of AR also prevented CLP-induced COX-2, iNOS and HMGB-1 in heart, kidney and spleen. Our results showed that the inhibition of AR significantly prevented the polymicrobial sepsis-induced increase in inflammatory markers and thus indicate the use of AR inhibitors as anti-inflammatory agents.
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影响因子：
4.8
作者：
Ramana, KV;Chandra, D;Srivastava, SK
通讯作者：
Srivastava, SK
影响因子：
9.6
作者：
Spapen, H;Zhang, HB;Huyghens, L
通讯作者：
Huyghens, L
DOI：
10.2165/00024677-200403040-00006
发表时间：
2004-01-01
期刊：
Treatments in endocrinology
影响因子：
--
作者：
Hamada, Yoji;Nakamura, Jiro
通讯作者：
Nakamura, Jiro
影响因子：
7.4
作者：
Ramana, Kota V.;Reddy, Aramati B. M.;Srivastava, Satish K.
通讯作者：
Srivastava, Satish K.
影响因子：
3.8
作者：
Ramana, Kota V.;Srivastava, Satish K.
通讯作者：
Srivastava, Satish K.